Pathology of vascular lung Diseases

Question 1

Normal Pulmonary blood pressure

Answer 1

1/8 of systemic blood pressure

Question 2

Groups of PH

Answer 2

Pulmonary arterial HPN
PH with left heart disease
PH associated with lung disease and/orhypoxemia
PH due to chronic thrombotic and/or embolic disease
Miscellaneous PH
Idiopathic arterial HPN
Familial form of mulmonary arterial HPN

Question 3

cell surface protein belonging to TGF-B which binds a varaiety of cytokines. Signalling in vascular smooth msucles which causes inhibition of proliferation and favors apoptosis

Answer 3

BMPR2

Question 4

Tufts of capillary formation producing a network of web; spans the lumens of thin walled arteries; resembles glomerulus

Answer 4

Plexiform lesion

Question 5

Diffuse Pulmonary Hemorrhage Syndromes

Answer 5

Goodpasteur syndrome
Idiopathic pulmonary hemosiderosis
Wegener granulomatosis

Question 6

Kidney and lung injury caused by circulating autoantibodies against the noncollagenous domain of the alpha-3 chain of collagen IV

Answer 6

Goodpasteur syndrome

Question 7

goodpasteur syndromes

Answer 7

In the kidneys: Proliferative, rapidly rogressive glomerulonephritis

Inthe lungs: necrotizing hemorrhagic interstitial pneumonitis

Question 8

Intermittent, diffuse alveolar hemorrhage. Usually in young children, Productive cough, hemoptysis anemia, weight loss, associated with diffuse pulmonary infiltration

Answer 8

Idiopathic pulmonary hemosiderosis

Question 9

Autoimmune disease invoving the upper respiratory tract and/or lungs

Answer 9

Wegener granulomatosis