Pathology of SCC and BCC- O'Donnell Flashcards
What is the most common NMSC?
BCC
AKs are premalignant for what?
SCC
Invasive SCC arise from what?
These will most likely arise from an AK; not from a SCC in situ.
Describe the Histological features of an AK
- Hyperkeratosis
- Parakeratosis
- Basal Cell layer Atypia
Note: Basal layer will show large irregular nuclei in disarray.
Aside from an AK or Sun exposure, what else can cause the development of SCC in situ?
- HPV
- Arsenic Exposure
What is Erythroplasia of Queyrat?
SCC of the penis
Describe the histology of SCC in situ
- Thin Parakeratosis
- Abnormal tripolar mitotic figures
- Full thickness squamous dysplasia
- Wind blown look
What is a cutaneous horn associated with?
Associated with:
- AK
- SCC
- SK
- Verruca
Most SCC develop secondary to which form of UV exposure?
UVB
What are the factors that influence SCC metastasis?
- Tumor size
- Immunosuppression
- Neotropism
Describe the histological features of Keratinocyte dysplasia in SCC
- Nuclear enlargement
- Prominent Nucleoli
- Abnormal Mitotic figures
-Eosinophilic and Reduced Cytoplasm
What are some key findings that make the prognosis of SCC less favorable?
- Poorly differentiated SCC
- Refractile internal elastic lamina signifying muscular artery invasion.
- SCC neurotropism
- Vascular invasion
What is the most common cutaneous skin cancer? Name a good feature about its behavior
- BCC
- Rarely metastatic
Name some histological features of BCC
- Retraction artifacts (separation of tumor from the stroma)
- Nests of Basal Cells (small and blue)
- Peripheral Palisading
- Mucin
Where is the carcinoma attached in the superficial type BCC?
The tumor is attached to the epidermis.
