Pathology of Fallopian Tubes and Ovaries Flashcards
When does development derive to male and female?
Week 7 of gestation
What determines if an embryo is male or female?
Presence of SRY gene (male)
What do the gonads arise from?
Embryonic urogenital ridges.
What ducts form male structures?
Wolffian/mesonephric
What ducts form female structures?
Mullerian/paramesonephric
What does the SRY gene do?
Directs the gonad to become a testis with spermatogoonia, leydig and sertoli cells.
What stimulates the development of the mesonephric duct structures?
Testosterone
What happens in the absence of testosterone during development?
Mesonephric duct structures atrophy.
What is the role of dihydrotestosterone in development?
Promotes development of prostate, penis and scrotum.
In males, what causes regression of the paramesonephric ducts?
Anti-mullerian hormone from sertoli cells.
What structures do the mesonephric ducts go on to form in males?
Rete testes, efferent ducts, epididymis, vas deferens, seminal vesicles, trigone of bladder.
In males, what does the urogenital sinus go on to form?
Bladder (except trigone), prostate, bulbourethral glands, urethra.
What does the gonad become in females with no SRY gene?
An ovary with oogonia and stromal cells.
What do the paramesonephric ducts form in females? What causes this?
Oviducts, uterus, cervix and upper third of vagina.
This happens due to the absence of AMH.
In females, what does the urogenital sinus give rise to?
Bulbourethral glands, lower 2/3rds of vagina.
