Pathology of Breast Disease Flashcards
What are examples of benign breast conditions?
- Fibrocystic change
- Fibrosis, adenosis, cysts, apocrine metaplasia, ductal epithelial hyperplasia (usual type and atypical)
- Fibroadenoma
- Circumscribed mobile nodule in reproductive age
- Other adenomas
- Tubular adenoma and lactating adenoma
- Intraduct papilloma
- Lactiferous ducts, nipple discharge
- Fat necrosis
- Duct ectasia
What are examples of fibrocystic changes to the breast?
- Fibrosis, adenosis, cysts, apocrine metaplasia, ductal epithelial hyperplasia (usual type and atypical)
What is fibroadenoma?
Proliferation of epithelial and stromal elements
What is the most common breast tumour in young adult woman?
Fibroadenoma
What are the different types of fibroadenoma?
- Intracanalicular pattern
- Ducts distorted elongated
- Pericanalicular pattern
- Ducts not compressed
What are characteristics of fibroadenoma?
- Well-circumscribed, freely mobile, no painful mass
What is the management for fibroadenoma?
- May regress with age
Describe the epidemiology of tubular adenoma (how common compared to fibroadenoma, young/older woman)?
- Less common than fibro adenomas
- Young woman
What are characteristics of tubular adenoma?
- Uniform sized ducts
What is lactating adenoma?
Enlarging masses during lactation or pregnancy:
- Prominent secretory change
Describe the epidemiology of intraduct papilloma (young/middle/older woman)?
- Usually middle aged woman
What are characteristics of intraduct papilloma?
- Nipple discharge, bloody
What is the aetiology of fat necrosis?
- History of antecedent trauma, surgery
What is seen in the histology for fat necrosis of the breast?
- Histiocytes with foamy cytoplasm
- Lipid-filled cysts
- Fibrosis, calcifications, egg shell on mammography
What is a possible complication of fat necrosis?
- Can stimulate carcinoma
What are characteristics of phyllodes tumour?
- Fleshy tumour, leaf-like pattern and cysts on cut surface
- Circumscribed, connective tissue and epithelial elements
What are possible complications of phyllodes tumour?
- Rapid growing so is borderline malignant
- Metastases are haematogenous
What are the 5 subtypes of molecular classification for breast carcinoma?
- ER and luminal A
- Luminal B
- Basal
- Her2
- Normal breast like
![](https://s3.amazonaws.com/brainscape-prod/system/cm/323/545/548/a_image_thumb.png?1602368170)
What molecular classification of breast carcinoma is most common?
Luminal A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/323/545/555/a_image_thumb.png?1602368216)
For each molecular subtype of breast carcinoma, are they positive or negative for:
- ER
- PR
- HER2
![](https://s3.amazonaws.com/brainscape-prod/system/cm/323/545/566/a_image_thumb.png?1602368264)
What is the aetiology for breast carcinoma?
- Different breast lesions have potential to become cancer
- Epithelial proliferation without atypia – RR 1.5-2x
- With atypia ductal or lobular – RR 4-5x
- LCIS – RR 8-10x
- DCIS – RR 8-10x