Pathology of Ageing + Comprehensive Geriatric Assessment Flashcards
What is fundamental of geriatrics (frailty NOT age)
- Routine investigations
Treat any infection - urine / CXR / ECG (routine) Stop drugs Fluid Bowel - PR Mobility Nutrition
Why are people getting older
LE rising and fertility falling Increased resources Better economic conditions Improved screening tests Better outcomes following major events
What are the theories of ageing
Stochastic - cumulative / random damage
Programmed
Homeostasis failure
What does ageing do to the kidney
GFR decreases
Why does creatinine levels stay the same as we age
Because we lose muscle mass so less creatinine produced but clearance has decreased
What happens to systolic, diastolic and CO
Systolic increases
Diastolic decreases
CO decreases
What is the importance of diastolic pressure
It is what keeps you upright so if BP low then you prevent stroke but more likely falls and fracture
What happens to TLC and VC
TLC stays the same
VC decreases
What is the body’s response to cold stress in frailty
Reduced vasoconstriction
Reduced metabolism
What is the body’s response to heat stress in frailty
Reduced sweat output
Reduced skin blood flow
Smaller increase in CO
Less redistribution of blood flow from renal and splanchnic
What is Frailty
Progressive dyshomeostasis
Leading to impairment of organ function and increased susceptibility to environmental stress
REDUCED ABILITY TO WITHSTAND ILLNESS WITHOUT LOSS OF FUNCTION
Increased vulnerability
Risk of further deterioration with minimal stress
What are the impacts of ageing / frailty
Social isolation
Higher risk of long term care
Increased co-morbidites and polypharmacy
ADR
Evidence gap in trials for medication
Increased variability in organ function of different people
Disruption in multiple health domains
Different presenting S+S
Dyshomeostasis in one system leads to lots involved
How does hyperthyroid classicaly present
Tremor
Anxiety
Weight loss
Diarrhoea
How does hyperthyroid present in frailty
Depression
Cognitive impairment
Muscle weakness
HF, angina, AF
What are the different health domains (need to deal with all in frailty / CGA
Medical - co-morbid / RV med / problem list / ACP
Psychological - mood / cognition (4AT) / anxieties
Functional - mobility/ ADL
Behavioural - eating / hobbies / job / smoking
Nutritional - MUST
Spiritual
Environmental - housing / heating / telehealth / transport
Social - support / abuse
Societal