Pathology of ageing Flashcards
1
Q
What happens to the ability of cells to divide as they age?
A
Decreases
2
Q
what determines telomere length?
A
parentally inherited
associated with parental lifespan
3
Q
Give some examples of damage that cells can accumulate
A
cross linking of proteins cross-linking or mutations of DNA loss of calcium influx controls damage to mitochondrial DNA loss of DNA repair mechanisms peroxidation of membranes free radical generation telomere shortening accumulation of toxic by-products of metabolism time-dependent activation of ageing and death genes
4
Q
State some signs and symptoms of ageing
A
dermal elastosis osteoporosis cataract dementia sarcopaenia deafness prostatic hyperplasia
