Pathology - Liver Flashcards

1
Q

what is alcoholic liver disease caused by

A

direct toxicity of alcohol to liver cells

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2
Q

what is occurring with alcoholic liver disease

A

alcohol is being turned into acetaldehyde

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3
Q

true or false; acetaldehyde is more toxic to the liver than alcohol

A

true

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4
Q

in alcoholic liver disease inflammation of the liver occurs; long-term drinking causes what

A

persistent inflammation and leads to fibrosis and cirrhosis

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5
Q

what is happening to the liver in cirrhosis

A

normal tissue is destroyed and replaced by scar tissue

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6
Q

the addition of scar tissue to the liver causes what

A

a diminished ability of the organ to function properly

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7
Q

if the liver is not functioning properly what processes are hindered

A

circulation of blood through the liver and reduced ability to remove toxins from the body

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8
Q

what is the common cause of cirrhosis

A

alcoholism and hep C

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9
Q

what are other less common causes of cirrhosis

A

blocked bile ducts, drugs, toxins, infections, some inherited diseases

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10
Q

true or false; obesity is unrelated to cirrhosis

A

false, it is being suggested that obesity can be a risk factor for cirrhosis

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11
Q

alcohol blocks the liver’s metabolism of _____, ______, and ______

A

proteins, fats, and carbohydrates

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12
Q

in early stages of cirrhosis the appearance is of the liver is known as a _______

A

“fatty liver”

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13
Q

true or false; in the early stage cirrhosis the damage is reversible

A

true, if the cause is removed the damage can be reversed

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14
Q

what are the damaged and dead cells replaced by

A

fibrous tissue

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15
Q

with he addition of fibrous tissue to the liver what occurs

A

fibrosis

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16
Q

last stage cirrhosis is characterized by what

A

fibrous scars that disrupt the makeup of the liver

17
Q

how does the liver appear in last stage cirrhosis

A

a small liver

18
Q

why causes the liver to be in failure during last stage cirrhosis

A

liver is unable to detoxify ammonia

19
Q

if the liver is unable to detoxify ammonia what can it lead to

A

hepatic coma and death

20
Q

cirrhosis can cause abnormalities in the brain; what are they called

A

hepatic encephalopathy

21
Q

what are the complications of cirrhosis

A

edema, ascites, bruising, bleeding, jaundice, gallstones portal hypertension, varices, diabetes, and liver cancer

22
Q

true or false; during last stage cirrhosis damage can still be reversed

A

false; treatment can only stop or delay further progression

23
Q

is cirrhosis considered an additive or destructive disease

24
Q

what are the causes of fatty liver

A

alcohol abuse and obesity

25
where are the fatty tumors commonly located within the liver
the anterior and lateral aspect of the falciform ligament
26
define hepatitis
inflammation of the liver cells
27
what occurs in the liver when hepatitis is severe
cirrhosis
28
what are the three types of hepatitis that may result in cirrhosis; describe the conditions
deficiency hepatitis: chronic alcoholism; deficient diet; malnutrition toxic hepatitis: drugs can result in necrosis of the liver viral hepatitis: six types
29
what are the six types of viral hepatitis and their causes
``` hep A: fecal contamination hep B: blood hep C: blood hep D: blood hep E: fecal contamination hep F: feces contaminated food or water hep G: blood ```
30
define jaundice
yellowish cast to the skin and clear of the eyes due to excess bilirubin in the blood
31
true or false; jaundice is considered a disease
false; it results from another issue and not considered a disease in itself
32
name the ways that bilirubin can accumulate in the blood
medical jaundice: non obstructive | surgical jaundice: obstructive
33
what is the most common benign neoplasm of the liver
heamngiomas
34
any tumor of the liver is called a
hepatoma
35
a primary carcinoma of the liver presents as what | where is it most common
massive nodular or diffuse appearance of the parenchyma | more common in the right lobe
36
true or false; hepatomas have a low mortality rate
false; high mortality is associated with hepatomas