Pathology - Liver Flashcards
what is alcoholic liver disease caused by
direct toxicity of alcohol to liver cells
what is occurring with alcoholic liver disease
alcohol is being turned into acetaldehyde
true or false; acetaldehyde is more toxic to the liver than alcohol
true
in alcoholic liver disease inflammation of the liver occurs; long-term drinking causes what
persistent inflammation and leads to fibrosis and cirrhosis
what is happening to the liver in cirrhosis
normal tissue is destroyed and replaced by scar tissue
the addition of scar tissue to the liver causes what
a diminished ability of the organ to function properly
if the liver is not functioning properly what processes are hindered
circulation of blood through the liver and reduced ability to remove toxins from the body
what is the common cause of cirrhosis
alcoholism and hep C
what are other less common causes of cirrhosis
blocked bile ducts, drugs, toxins, infections, some inherited diseases
true or false; obesity is unrelated to cirrhosis
false, it is being suggested that obesity can be a risk factor for cirrhosis
alcohol blocks the liver’s metabolism of _____, ______, and ______
proteins, fats, and carbohydrates
in early stages of cirrhosis the appearance is of the liver is known as a _______
“fatty liver”
true or false; in the early stage cirrhosis the damage is reversible
true, if the cause is removed the damage can be reversed
what are the damaged and dead cells replaced by
fibrous tissue
with he addition of fibrous tissue to the liver what occurs
fibrosis
last stage cirrhosis is characterized by what
fibrous scars that disrupt the makeup of the liver
how does the liver appear in last stage cirrhosis
a small liver
why causes the liver to be in failure during last stage cirrhosis
liver is unable to detoxify ammonia
if the liver is unable to detoxify ammonia what can it lead to
hepatic coma and death
cirrhosis can cause abnormalities in the brain; what are they called
hepatic encephalopathy
what are the complications of cirrhosis
edema, ascites, bruising, bleeding, jaundice, gallstones portal hypertension, varices, diabetes, and liver cancer
true or false; during last stage cirrhosis damage can still be reversed
false; treatment can only stop or delay further progression
is cirrhosis considered an additive or destructive disease
additive
what are the causes of fatty liver
alcohol abuse and obesity