Pathology: Inflammation Flashcards
1
Q
What is the cause of inflammation?
A
Injury
2
Q
What are causes of cellular injury?
A
- Infection
- Trauma
- Foreign bodies
- Immune reaction
- Necrosis
3
Q
What is the response to cellular injury?
A
- Vascular Changes
- Cellular Changes
- Chemical Mediators - pain
- Morphologic Patterns
4
Q
What are vascular changes caused by injury?
A
- Vasodilation
* Slows blood flow and allows for margination
5
Q
What are vascular changes mediated by?
A
- Histamine
* Nitric oxide
6
Q
What clinical signs are caused by vasodilation?
A
- Calor - increased heat
* Rubor - erythema
7
Q
What are cellular changes in response to injury?
A
- White cell margination
- Rolling
- Adhesion
- Migration
8
Q
Describe the normal flow of blood
A
- Blood flows centrally within a vessel
9
Q
What are changes to blood flow caused by vasodilation?
A
- Rate of flow slows
- Cells are able to move peripherally (especially larger white cells)
- Known as margination
10
Q
What is white cell margination?
A
- WBCs move to periphery of blood vessel due to slow blood flow
11
Q
How do WBCs adhere to blood vessel walls if they are usually slippy?
A
In inflammation, the vessels express various proteins on lumen surface that have a matching protein on white cell surface
12
Q
slide 16
A
slide 16
