Pathology

Question 1

Which inflammatory myopathy is medicated by CD 8+ T-cells?

Answer 1

Polymyositis

Question 2

Which inflammatory myopathy may occur in children?

Answer 2

Dermatomyositis occurs in both children and adults -while polymyositis arises in pts 40-70 yoa -inclusion body myositis occurs in males > 50 yoa

Question 3

Which inflammatory myopathy is associated w/ proximal weakness?

Answer 3

Both polymyositis and dermatomyositis are associated w/ proximal weakness -while inclusion body myositis is associated w/ distal weakness

Question 4

Which inflammatory myopathy is associated w/ microvascular injury?

Answer 4

Dermatomyositis: primary process is vascular injury

Question 5

Which inflammatory myopathy is associated w/ malignancy?

Answer 5

Dermatomyositis

Question 6

Which inflammatory myopathy has no effective treatment?

Answer 6

Inclusion body myositis

Question 7

Rimmed vacuoles are a classic pathologic finding of which inflammatory myopathy?

Answer 7

Inclusion body myositis

Question 8

Which inflammatory myopathy is associated w/ myalgia?

Answer 8

Polymyositis -myalgia = muscle pain `

Question 9

Which inflammatory myopathy is medicated by B and CD4+ T-cells?

Answer 9

Dermatomyositis

Question 10

What type of atrophy occurs in dermatomyositis?

Answer 10

Perifascicular atrophy -primary process is vascular injury and blood vessels are locate din the center of the muscle fascicle => the atrophy will occur most at the periphery (farthest away from the BV) = perifascicular

Question 11

Heliotrope rash is a classic finding of which inflammatory myopathy?

Answer 11

Dermatomyositis

-itchy rash around the eyes

Question 12

What are ragged-red fibers a classic finding of?

Answer 12

Mitochondrial myopathies

Question 13

What is Grower’s sign a classic finding of?

Answer 13

Grower’s sign = physical exam finding of Duchenne’s muscular dystrophy

-pts have to use their hands to get up from the ground (b/c no muscles in their legs)