Pathology Flashcards
BCR-ABL
Oncogene
MOA: Translocation of chromosome 9 to 12
Associated tumors: CML, ALL
Gene product: Tyrosine Kinase
bcl-2
Oncogene
MOA: over expression of bcd-2 which inhibits apoptosis allowing for continuous cell growth.
Associated Tumors: Follicular and undifferentiated lymphomas.
Gene product: Anti-apoptotic molecule (inhibits apoptosis)
BRAF
Oncogene
Associated tumor: Melanoma
Gene Product: Serine/threonine kinase
c-kit
Oncogene
MOA: Point mutation
Associated tumor:Gastrointestinal stromal tumor (GIST)
Gene product: Cytokine receipts (for stem cell factor)
c-myc
Oncogene
MOA: Translocation of 8 and 14
Associated tumors: Burkitt Lymphoma
Gene product: Transcription factor
HER2/neu (c-erbB2)
Oncogene
MOA: Amplification/ Over expression
Associated tumors: Breast, ovarian and gastric carcinomas
Gene product: Tyrosine Kinase
L-myc
Oncogene
MOA: Amplification
Associated tumor: Lung tumor
Gene product: Transcription factor
N-myc
Oncogene
MOA: Amplification
Associated tumors: Neuroblastoma
Gene product: Transcription Factor
ras
Oncogene
MOA: Point Mutation
Associated Tumors: Colon cancer, lung cancer, pancreatic cancer
Gene product: GTPase
ret
Oncogene
MOA: point mutation of tyrosine kinase
Associated Tumors: MEN 2A and 2B
Gene product: Tyrosine kinase
APC
Associated Tumor: Colorectal Cancer (associated with FAP)
BRCA1/BRCA2
Associated Tumor: Breast and ovarian cancer
Gene product: DNA repair protein
CPDA4/SMAD4
Associated Tumor: Pancreatic cancer
Gene product: DPC- Deleted in Pancreatic Cancer
DCC
Associated Tumor: colon cancer
Gene product: DCC- Deleted in Colon Cancer
MEN1
Associated tumor: MEN type 1
