Pathology Flashcards
How are the ovaries positioned?
Varies in position
Influenced by uterine location and ligament attachments
What do the ovaries look like structurally?
Paired, almond shaped structures situated one on each side of the uterus close to the lateral pelvic wall
Where are the ovaries found in an anteflexed midline uterus?
Laterally or posterolaterally
What is the normal sonographic appearance of the ovaries?
Homogeneous echotexture
May exhibit central, more echogenic medulla
Small anechoic or cystic follicles - peripherally in cortex
Appearance varies with age and menstrual cycle
What are the 3 phases of the menstrual cycle?
Menstruation - Days 1 to 4
Proliferative - Days 5 to 14
Secretory or Luteal - Days 15 to 28
What happens during the proliferative phase?
Many follicles develop and increase in size until about day 8 or 9 of cycle due to stimulation by both FSH and LH
How many follicles become dominant per cycle and what is its measurement at time of ovulation?
One dominant follicle
Reaching 2.0-2.5 cm at time of ovulation
During the proliferative phase, what is Cumulus Oophorus?
An eccentrically located, cystic like, 1 mm internal mural protrusion
During the proliferative phase, what does visualization of a cumulus indicate?
A mature follicle and imminent ovulation
No reproducible sonographic sign reliable
Other follicles become atretic
During the late proliferative phase, what develops if fluid in the nondominant follicles do not reabsorb?
Follicular cyst
During the late proliferative phase, what happens to the dominant follicle?
Usually disappears immediately after rupture at ovulation
Describe what a follicle occasionally looks like during the late proliferative phase.
Follicle decreases in size and develops a wall that appears crenulated (scalloped)
When is fluid in the cul de sac commonly seen?
After ovulation and peaks in early luteal phase
What is commonly seen in a normal ovary?
Multiple small, punctuate, echogenic foci
Following menopause, what happens to the ovary and follicles?
The ovary atrophies and follicles disappear with increasing age
After a hysterectomy, what happens to the ovaries?
Ovaries can be difficult to visualize with ultrasound
What is the ovary volume of an adult menstruating female?
As large as 22 cc
Ovary volume of 9.8 plus or minus 5.8 cc
What ovary volume is considered abnormal for a postmenopausal patient?
More than 8 cc
When the ovary volume is _______ that of the opposite side! this should be considered abnormal, regardless of actual size.
Twice
What is the ovary’s function?
To mature oocytes until ovulation under influence of LH and FSH from the pituitary gland
What is the ovary synthesizing?
Androgens (male hormones) and converts them to estrogen (female hormones)
What is produced after ovulation occurs and how do this help a pregnant women?
Produces progesterone after ovulation to sustain early pregnancy until placenta can do so at 10-12 weeks of gestation
What size does the dominant follicle enlarge to about 10 days into the mid and late follicular phases of cycle?
Enlarges from 3 mm to 24 mm
What follows the enlargement of the one dominant follicle?
Ovulation
Ovulation causes what?
The corpus luteum or an abnormal unruptured follicle can persist as simple or complex cystic structure from 1-10 cm
When might surgical intervention be considered for a cyst?
If a cyst is greater than 6 cm for more than 8 weeks
What is the most common mass found in an ovary?
A simple follicular cyst - benign
VERY IMPORTANT
What is the criteria of a cyst?
Anechoic, well defined borders, thin smooth walls, round or oval, through transmission
Describe postmenopausal ovaries…
Small anechoic cysts may be seen
Can disappear or change in size over time
Surgery is recommended for postmenopausal cysts greater than 5 cm and for those contains internal septations and/or solid nodules
What are 7 common cystic or complex ovarian masses?
Follicular cyst Corpus luteum cyst with pregnancy Cystic teratoma Paraovarian cyst Hydrosalpinx Endometrioma Hemorrhagic cyst
What is a complex mass?
Any simple cyst that hemorrhages as it involutes
What are 3 classic differential considerations of complex adnexal masses?
Ectopic pregnancy
Endometriosis
Pelvic inflammatory disease (PID)
Name 5 specific complex masses…
Cystadenoma Dermoid cyst Tubo-ovarian abscess Ectopic pregnancy Granulose cell tumor
What is typical of all epithelial ovarian tumors?
Mixed solid to cystic ovarian masses
What are the 2 most common serous types of solid tumors?
Cystadenoma
Cystadenocarcinoma
During peak fertile years, what ratio of solid tumors are malignant? How about the ratio after the age of 40?
Fertile years - 1 in 15
After age of 40 - 1 in 3
More sonographically ________ the tumor, more likely to be ________, especially if associated with ________.
Complex
Malignant
Ascites
What is the epithelium of serous tumors?
Tubal in type
May be one or multiple cysts
What fraction of solid tumors are bilateral?
1/4
Tumors are large and offer fill pelvic cavity
Solid tumors mostly occur in women over what age?
40
What is helpful in determining the pathology of an ovary?
Color Doppler
Ovarian lesion vs pedunculated fibroid
What are 6 common solid masses?
Solid teratoma Adenocarcinoma Arrhenoblastoma Fibromyalgia Dysgerminoma Torsion
What does Doppler of the ovary help to differentiate?
Potential cyst from adjacent vascular structures
How can RI and PI be determined for the adnexal branch of the uterine artery, the ovarian artery, and the intratumoral flow?
Pulse Doppler - localized flow
When should patients with normal menstrual cycles be scanned for best results?
First 10 days of the cycle
Why is it best to scan during the first 10 days of the cycle?
Avoids confusion with normal changes in intraovarian blood flow because high diastolic flow occurs in luteal phase
What is the value of RI in distinguishing between benign and malignant adnexal masses?
Greater than 0.4 as normal RI in nonfunctioning ovary
Greater than 1 as normal PI
What are some signs that may be worrisome for malignancy?
Intratumoral vessels, low resistance flow, and absence of normal diastolic notch in Doppler waveform
Malignancies will have a lot more flow
When can abnormal waveforms be seen?
Inflammatory masses, metabolically active masses (ectopic pregnancy), and corpus luteum cysts
Mimicks cancer
______ is not a sensitive indicator of malignancy.
RI
Formula for PI?
Mean velocity
Formula for RI?
Systolic peak velocity
Increased diastolic flow suggests what?
Neovascularity and likelihood of a malignancy
Masses showing what are usually benign?
Complete absence or minimal diastolic flow
Very elevated RI and PI values
Diastolic notch in early diastole
What cysts result from normal function of ovary?
Functional cysts
Functional cysts cause what?
Ovarian enlargement in young women due to hormonal influences
MOST COMMON
Functional cysts include what?
Follicular
Corpus luteum
Hemorrhagic
Theca-lutein
Describe 5 things about functional cysts…
Occur when dominant follicle does not succeed in ovulating and remain active though immature
Unilateral
Thin walled, translucent, have watery fluid
Grow 1-8 cm
Usually disappear spontaneously by resorption or rupture
What are clinical findings of follicular cysts?
Asymptomatic to dull
Adnexal pressure and pain
Abnormal ovarian function
Torsion of ovary resulting in severe pain
Describe 4 things about corpus luteum cysts…
Result from hemorrhage within persistently mature corpus luteum
Filled with blood and cystic fluid
Grows 1-10 cm ; complex
May accompany intrauterine pregnancy (IUP)
What are clinical findings of corpus luteum cysts?
Irregular menstrual cycle
Pain
Mimic ectopic pregnancy
Rupture
What are sonographic findings of corpus luteum cysts?
“Cystic” type of lesion
May have internal echoes secondary to hemorrhage and increased color
What are hemorrhagic cysts?
Internal hemorrhage may occur in follicular cysts or, more commonly, in corpus luteal cysts
Will experience acute onset of pelvic pain
Septations in hemorrhagic cysts are caused by what?
Blood clotting
Describe 4 things about hemorrhagic cysts…
Hyperechoic; may mimic a solid mass
Smooth posterior wall and posterior acoustic enhancement
Diffuse low level echoes
Internal pattern becomes more complex
Theca-lutein cysts are…
Large
Bilateral
Multiloculated
Seen in 30% of patients with trophoblastic disease
What are theca-lutein cysts associated with?
High levels of hCG due to molar pregnancies
What are clinical and sonographical findings for theca-lutein cysts?
Clinical - nausea, vomiting
Sonographic - multilocular cysts in both ovaries
Name 3 ovarian syndromes…
Ovarian hylerstimulation
Polycystic ovarian
Ovarian remnant