Pathology 2

Question 0

What is the clinical course of diabetic nephropathy?

Answer 0

Onset of diabetes to overt diabetic nephropathy (proteinuria >.5/24 hrs) usually 20 yrs or more
ESRD in another 5-10

Question 1

What happens in extra capillary epithelial cell proliferation (crescent)?

Answer 1

RBC leaking and decrease filtration
Hematuria and acute renal failure
RBCs in urine, increase serum creatinine and BUN

Question 2

How can you differentiate between wegeners, microscopic poly angiitis, and churg Strauss that all have lung and kidney involvement?

Answer 2

Wg - no asthma, granulomas
Mp - no asthma, no granulomas
Cs - asthma, no granulomas

Question 3

What does an inflammatory infiltrate do in glomerular diseases?

Answer 3

RBC leaking and decreased filtration
Nephritic syndrome
RBCs in urine, increased serum creatinine and BUN
Examples are post infectious, proliferative, MPGN

Question 4

What are the five types of renal injury seen with multiple myeloma?

Answer 4

Myeloma cast nephropathy - most common
Amyloidosis
Light chain deposition disease
Heavy chain deposits disease
Myeloma cell infiltrates in kidney - least common

Question 5

What characterizes myeloma cell infiltrates in the kidney?

Answer 5

Monoclonal plasma cells in kidney parenchyma