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John's Cards > Pathology > Flashcards

Pathology Flashcards

1
Q

TTF1

A

lung and thyroid

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2
Q

WT1

A

peritoneal lining and serous

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3
Q

CD10

A

endometrial stroma

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4
Q

sarcomatous overgrowth

A

One 4X field without glands

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5
Q

what does WT1 help differentiate between?

A

gyn and breast; + for serous gyn tumors

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6
Q

endocervical glands

A

apical mucin that appears blue gray; not seen in endometrial glands

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7
Q

normal pap smear cell morphology

A

low N/C ratio; pink = estrogen stimulated; blue = progesterone stimulated

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8
Q

endometrial hyperplasia

A

> 55% gland to stroma ratio

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9
Q

endometrioid adenocarcinoma grading

A

5-50% solid = grade 2

>50% solid = grade 3

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10
Q

serous histogy buzz word

A

“ships in the night”

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11
Q

p53 nuclear stain

A

mutated p53 has more abnormal p53 around; thus there is increased staining in a p53 mutated tumor; this can correlate to more agressive tumor behavior

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12
Q

foamy cells within stroma

A

dead cells that have been devoured by macrophages

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13
Q

typical stain panel in gyn

A

ER/PR/CEA/vimentin

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14
Q

vimentin

A

mesenchymal/stromal; stains + in endometrium

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15
Q

p16

A

cervical tumors

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16
Q

villoglandular

A

fibrovascular chords

17
Q

CDX2

A

specific to colon ca; if CK20+ think GI

18
Q

hematoxalyn

A

nuclear stain

19
Q

eosin

A

cytoplasm and stromal stain

20
Q

PAS

A

general stain for fungal elements; green background

21
Q

endocervical adeno ca

A

CK7+/CK20 -, CEA+

22
Q

mucinous ovarian ca

A

CK7+/CK20+ (CDX2 variable

23
Q

endometrial adeno ca

A

CK7+/CK20-, vimentin +, ER/PR+

24
Q

SCC of the cervix

A

CK7+/CK20-

25
Q

CK7/CK20

A

CK7: Type II keratin of simple nonkeratinizing epithelia; molecular weight 54 kDa
● Found in breast, lung, ovary and urothelium, but usually NOT in GI or stratified squamous epithelium
CK:20: •Epithelial marker (MW 46 kDa) with restricted expression compared to CK7

John's Cards (8 decks)

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