Pathology

Question 1

Spindle cells

Answer 1

Pleomorphic spindle cell tumour
Dx - leiomyosasrcoma (SMA, desmin)
DDx - leiomyoma. DFSP (CD34). Other spindled - SCC (p63, keratin), melanoma (S100, SOX10, HMB45, PRAME), AFX (vimentin)
SLAMDUNK, Kaposi (HHV8, CD31, CD34), angiosarcoma (CD31, CD34)