Pathogenic Mechanisms of Bacteria Flashcards
Gland type that secretes an oily waxy matter to lubricate skin and hair
Sebaceous glands
Protein found in mucosal secretions that binds iron with a high affinity thereby outcompeting most bacteria
Lactoferrin
Found in blood/tissue
Function is to limit iron availabilty
Transferrin
Found in tissue
Functions include phagocytosis and antigen presentation
Macrophage
Found in blood/tissue
Functions include phagocytosis, opsonization, bactericidal
Complement
Found in blood
Functions include cytokines, immune functions
Monocytes
Found in blood/tissue
Functions include phagocytosis, immune function
PMN’s
Disease causing microorganism
Pathogen
The physiological processes involved in the generation of clinical signs of disease
Pathogenesis
Capacity of a microbe to cause disease
Pathogenicity
or
Virulence
Ability of a microbe to cause disease efficiently or inefficiently
Virulence
Component of a pathogen that contributes to its disease-producing potential
Virulence factor
Criteria designed to establish causal relationship between causative microbe and a disease
Koch’s postulates
Koch’s postulates
Organism found in human/animals with infectious disease but not healthy ones
Organism must be isolated and grown in pure culture
Organism grown in pure culture must initiate disease when re-inoculated into susceptible animals
Organism must be re-isolated from experimentally infected animals
Degree of pathogenicity
Virulence
3 routes that bacteria can penetrate the gut epithelial layer
M cells
Adherence of fimbriae/pili to epithelial surface
Dendritic cells
Bacterial surface proteins that provoke phagocytic ingestion of the bacteria by host cells are called
Invasins
Bacterial cell surface proteins that are important for adherence to host cells
Adhesins
Prevents phagocytosis of bacterial cell and resists complement activation
Capsule
Helps make iron available to bacteria
Siderophores
