pathogenesis cards

Question 1

systemic sclerosis /morphea

Answer 1

1) vascular dysfunction- impaired angiogenesis
-endothelial injury, luminal occlusion, hypoxia -profibrotic cytokines fibroblast activation,collagen depostion,
-PNF capillaries, pulmonary artery, Raynaud’s, digital ulcer, sclerodermal renal crisis hypertension
2) immune dysregulation
anticentromere antitopoisomerase 1 ab
Th2 predominent IL4, IL13 profibrotic cytokines TGFb CTGF
3) fibrosis
-incr synthesis/depostion collagen PG fibronectin/fibrillin, b integrin

Question 2

pemphigus

Answer 2

circulating IgG Ab to Dsg 1/3

desmoglein compensation theory

Question 3

lupus

Answer 3

keratinocyte

Question 4

dermatomyositis

Answer 4

1) genetics
2) cellular immunity/apoptosis/humoral immunity
3) infectious/drugs/vaccine
4) malignancy