PATHOGENESIS AND CLINICAL MANIFESTATIONS

Question 1

(STI) in both men and women; characterized by invasion of the mucous membranes of the genital tract causing inflammation

Answer 1

Gonorrhea

Question 2

Primary site of Genital gonorrhea infection in males

Answer 2

urethra

Question 3

Symptoms of urethritis occur in 90-95% of infected males

Answer 3

‣ dysuria (burning sensation during urination)

‣ purulent urethral discharge (yellow, creamy pus)

Question 4

Primary site of Genital gonorrhea infection in females

Answer 4

endocervix

Question 5

Symptoms of this disease occur in 10-20% of infected females
‣ purulent cervicovaginal
discharge
‣ dysuria
‣ menorrhagia (intermenstrual bleeding)
‣ dyspareunia (painful vaginal intercourse)

Answer 5

endocervicitis

Question 6

manifested as salpingitis (infection of the Fallopian tubes), endometritis, and tubo-ovarian abscess.

Answer 6

pelvic inflammatory disease (PID)

Question 7

is a risk factor for ectopic pregnancy, infertility, chronic pelvic pain, and Fitz–Hugh–Curtis syndrome — a perihepatitis, an infection and inflammation of liver capsule and “violin string” adhesions of peritoneum to liver

Answer 7

Salpingitis

Question 8

gonorrhea as a sign of sexual abuse

Answer 8

after the newborn period and before puberty

Question 9

• Seen in MSM
• Over 90% are asymptomatic
• px have gonococcal infection at genital and/or rectal sites as well.

Answer 9

Oropharyngeal gonococcal infection

Question 10

• Seen primarily in MSM who practice unprotected receptive anal intercourse
• Women may also acquire rectal infections by receptive anal intercourse
• symptoms: mild pruritis to acute proctitis with anorectal pain and itching, a mucopurulent discharge, bleeding, tenesmus, and constipation 5 to 7 days following infection

Answer 10

Anorectal gonococcal infection

Question 11

• Painful, purulent conjunctivitis

- Occurs in adults who become infected by self inoculation of the eyes from genital secretions

Answer 11

Ocular gonococcal infection

Question 12

• An infection of the eye in newborns
• Acquired during passage through the birth canal of an infected mother.
• Initial purulent conjunctivitis occurs 2-5 days after birth, rapidly progresses and, if untreated, results in blindness.

Answer 12

Gonococcal ophthalmia neonatorum

Question 13

• spread of gonococci into the
  bloodstream
• Characterized by low-grade fever, painful, hemorrhagic skin lesions on the hands, forearms, feet, and legs; tenosynovitis and suppurative arthritis, usually of the knees, ankles, and wrists
• Complications include permanent joint damage, endocarditis, and rarely, meningitis

Answer 13

Disseminated Gonococcal Infection (DGI)