Pathogenesis

Question 1

How do deep pockets contribute to pathogenesis?

Answer 1

anaerobic conditions are protected

Question 2

dysbiosis definition?

Answer 2

mature microbial ecosystem in equilibrium with inflamed periodontium

Question 3

Most periodontitis not evident until?

Answer 3

late 30s-40s

Question 4

What % patients have severe generalized disease?

Answer 4

8-15%

Question 5

2 things that predict future perio problems

Answer 5

past history of perio disease

irregular professional maintenance

Question 6

Past perio problems predict future b/c? (4)

Answer 6

Means patient bacterial population consistent with disease progression
Anatomic results of prior diseases make it more difficult to maintain hygiene
Cellular phenotypes/genes changed
Absence is strong predictor of stability.

Question 7

Smoking mechanisms (3)

Answer 7

immunity change
collagen metabolism
wound healing

Question 8

smoking vs perio disease occurrence?

Answer 8

Greater recurrence
Higher edentulism
Dose dependent

Question 9

Genetics predicts how much of disease severity?

Answer 9

> 50%

Question 10

IL-1B levels vs perio disease?

Answer 10

IL-1B gene overexpression makes disease worse, blocking reduces

Question 11

Obesity does what to risk of periodontitis? treatment?

Answer 11

greater risk, increased progression, treatment less effective

Question 12

Obesity and inflammatory factors?

Answer 12

TNF, IL-1B, IL-6

Question 13

Periodontitis and systemic inflammation?

Answer 13

Higher CRP/inflammation

Question 14

Treating periodontitis and medical cost?

Answer 14

goes down!