Patho Test 1 Flashcards
2 types of feedback mechanism
1) negative feedback
2) positive feedback
3 components of feedback control
1) sensor
2) integrator/comparator/regulatory center
3) effector
Iatrogenic etiology
Caused by healthcare professional during treatment or diagnostic procedure
Clinical manifestations are investigated by acronym…
OPQRST
OPQRST means…
Onset Provocative Quality Region/radiation Severity Timing
Investigate symptoms asking about…
Location Quality Quantity Chronology Setting Aggravating/alleviating factors Associated manifestations Meanings to patient
Stages of the disease process…
Exposure Latent incubation Prodromal period Acute phase Remission Convalescence Recovery
Cells adapt by changing…
Size
Number
Type
Atrophy
Cell size decreases
Causes of atrophy
Disuse Denervation Loss of endocrine stimulation Inadequate nutrition Ischemia
Hypertrophy
Cell size increases which increases the cell functioning tissue mass
2 types of hypertrophy
1) physiologic - exercise
2) pathologic - hypertension
Hyperplasia
Cell number increases
Metaplasia
Reversible replacement of one cell type by another of same family
Response to chronic irritation
Reprogramming of stem cells
Dysplasia
Atypical form of hyperplasia
Changes to number size shape and organization
Precursor to cancer
Neoplasia
Abnormal proliferation of cells
Abnormally grow OR don’t die
Causes of cell injury
Hypoxia
Oxygen-derived free radicals
Impaired calcium homeostasis
Chemical injury
Reperfusion (hypoxia-reoxygenation) injury
Reperfused tissue must sustain loss of cells in addition to irreversibly damaged cells after ischemia
Reperfusion injury causes what major problem for remaining cells?
Highly reactive oxygen intermediates
OFR
Oxygen free radical
Examples of antioxidants
Alpha lipoid acid Vit A, C, E Coenzyme Q10 Selenium Polyphenols (green tea)
Parasympathetic
Rest and digest
Sympathetic
Fight or flight
GAS 3 structural changes
Enlarged adrenal glands
Decreased thymus gland
Gastrointestinal ulceration
3 stages of GAS
Alarm
Stage of resistance/adaptation
Stage of exhaustion
3 systems that respond to stress
Nervous
Endocrine
Immune
3 components of physiological stress
Stressor
Physical/chemical disturbance
Body’s counteracting response
3 types of flu virus
Type a, b, c
Type a flu virus subtype
H1n1
H1n2
H3n2
Thyrotropin releasing hormone (TRH)
Origin - hypothalamus
Target - anterior pituitary
Action - stimulates TSH
Corticotropin releasing hormone (CRH)
Origin - hypothalamus
Target - anterior pituitary
Action - stimulates ACTH
Gonadotropin releasing hormone (GnRH)
Origin - hypothalamus
Target - anterior pituitary
Action - stimulates LH and FSH
Growth hormone releasing hormone (GHRH)
Origin - hypothalamus
Target - anterior pituitary
Action - stimulates GH
Somatotropin release inhibiting hormone (SRIH)
Origin - hypothalamus
Target - anterior pituitary
Action - inhibits GH
Thyroid stimulating hormone (TSH)
Origin - anterior pituitary
Target - thyroid
Action - stimulates thyroid hormone
Follicle stimulating hormone (FSH)
Origin - anterior pituitary
Target - ovaries and testes
Action - stimulates ovarian follicles and sperm maturation
Luteinizing hormone (LH)
Origin - anterior pituitary
Target - ovaries and testes
Action - stimulates ovulation. Synthesize sex hormones
Growth hormone (GH)
Origin - anterior pituitary
Target - body
Action - stimulates protein synthesis and growth
Prolactin
Origin - anterior pituitary
Target - breasts
Action - stimulates milk production
Adrenocorticotropic hormone (ACTH)
Origin - anterior pituitary
Target - adrenal cortex
Action - secrete adrenal cortical hormones
Melanocyte stimulating hormone (MSH)
Origin - anterior pituitary
Target - skin cells
Action - stimulates melanin synthesis
Oxytocin
Origin - posterior pituitary
Target - breast and uterus
Action - stimulates milk ejection and contraction