Patho-Renal Flashcards
What is renal disease?
Any condition that reduces the ability of the kidneys to perform its primary function.
What are the 4 common markers of renal disease?
BUN (Blood Urea Nitrogen)
Serum Creatinine
Glomerular filtration
Creatinine Clearance
What is the functional unit of the kidney?
Nephron
What are some of the keep parts of the nephron?
Afferent arteriole-Brings blood to glomerulus
Efferent arteriole- Takes blood away from the glomerulus
Glomerulus- Serves as the entrance to renal tubular system and filters blood and acts as a filtration membrane
Juxtaglomerular apparatus: Detects low blood pressure, secretes renin.
Bowman’s capsule:
Proximal convoluted tubule:Site of reabsorption of filtered Na+, H2O, K+, HCO3-, and PO4-.
Site of secretion of H+, drugs, and other toxins.
Loop of Henle: Site of reabsorption of filtered Na+, and H2O.
Distal convoluted tubule: Site of reabsorption of filtered Na+, H2O, K+, HCO3-, and PO4-.
Site of secretion of H+, K+, and maintains acid/base balance tion of filtered H2O and primary determinant of concentration of urine.
Collecting duct: Site of action for ADH and reabsorption of filtered H2O and primary determinant of concentration of urine.
The movement of substances from the blood is called___
The movement of substances that have been filtered back into the blood stream is called______
The movement of substances from blood the blood stream into the renal tubules is called____ ___
Filtration
Reabsorption
Secretion
What is GFR?
The amount of blood that gets filtered every minute.
What is normal value for GFR?
120 ml/min. Values less than 120 min/ml indicate that the kidneys are not working well.
GFR is estimated by measuring serum creatinine (SCr) levels. T or F
True . When SCr levels go up, GFR goes down.
What is the equation (Cockcroft Gault) equation for figuring Creatinine clearance.
CrCl (mL/min) = (140-age) x Ideal Body Weight (IBW) x 0.85(female)/72 x SCr
- Age in years
- IBW in kilograms (use actual body weight if < IBW)
- SCr in mg/dL
What are the 4 primary functions of the kidneys?
- Fluid and electrolyte balance
a. Maintains normal blood pressure(BP) through regulation of fluid status and Na conc
-If BP increases, kidneys responds with increased fluid and Na excretion
-If BP decreases, kidneys responds with increased fluid and Na reabsorption.
b. Regulated through the actions of antidiuretic hormone (ADH) and the renin angiotensin-aldosterone system (RAAS).
Decrease in renal perfusion, low BP is detected by the Macula densa in the juxaglomerular apparatus in the kidney and responds by secreting renin. Renin converts angiotensinogen produced by the liver to angiostensin I which in turn is converted to angiostensin II by the action of angiotensin converting enzyme (ACE). The effects of Ang II are numerous:
-Causes the adrenal cortex to secrete aldosterone. Aldosterone secretion leads to the tubular reabsorption of NaCl, K+ excretion, and water retention.
- Causes sympathetic activity to increase.
-Causes the efferent arteriole of the glomerulus to vasoconstrict thus increasing BP.
-Causes the posterior pituitary gland to secrete ADH which activates the collecting duct to absorb water.
The net result is water and salt retention. Effective circulating volume increases. Perfusion of the juxaglomerular apparatus increases.
What are the 4 primary functions of the kidneys?
- Endocrine Function
o Secretes many hormones including erythropoietin and renin
o Responsible for production of active vitamin D - Acid Base Regulation
o Controls H+ ion (acid) concentrations in the bloodstream through regulation of H+ excretion and HCO3- (base) reabsorption - Elimination of waste products
o Filters waste byproducts including urea, uric acid, drugs, and other toxins from the bloodstream into the urine for excretion
Define Acute Kidney Injury (AKI)
An abrupt decrease in renal function that results in increased BUN and SCR (over baseline)
Time frame is essential in classifying AKI as acute.
o Occurs over hours-to-days even weeks
o Does not occur gradually over the course of years
o By definition, acute is renal dysfunction occurring for < 3 months.
Name the 3 components of AKI
Pre-Renal Acute Kidney Injury
Intrinsic Acute Kidney Injury
Post Renal Acute Kidney Injury
What are the stages for status/severity of AKI as determined by the National Kidney Foundation (NKF)?
Stage SCr Criteria
Stage 1 SCr increase >0.3 mg/dL OR
1.5-1.9 times baseline
Stage 2 SCr increase 2-2.9 times baseline
Stage 3 SCr increase > 3 times baseline OR
SCr >4 mg/dL
Define Pre-Renal Acute Kidney Injury
- An acute decline in renal function secondary to decreased renal blood flow or loss of autoregulation
- Regardless of etiology, decline in renal function can be attributed to a decreased intraglomerular pressure.
What is the physiologic basis of Pre-Renal Acute Kidney Injury?
• A minimum filtration pressure must be maintained in the glomerulus for adequate filtration to occur
•Two primary determinants of glomerular filtration pressure:
1. Renal Blood Flow (RBF)
2. Circulating Blood Volume (CBV)
• Autoregulation: The process by which RBF is maintained through constriction/dilation of the afferent and efferent arterioles
o Prostaglandins are responsible for dilation of the afferent arteriole
o Angiostensin II is responsible for constriction of the efferent arteriole
• When autoregulation capacity is exceeded, glomerular perfusion pressure drops
o GFR drops proportionate to the drop in perfusion pressure
o Water, electrolytes, and waste products are not filtered from the bloodstream into the renal tubule
Autoregulation capacity exceeded = Decreased glomerular perfusion = Decreased glomerular filtration = Decreased CrCl/GFR = Retention of waste products in the blood stream = Increased BUN and SCr = Pre Renal Acute Kidney Injury.