Patho of Spleen

Question 1

Splenomegaly

Answer 1

• splenic enlargement (over 13cm)
• usually results from systemic disease

Question 2

Causes of MILD splenomegaly
(slightly over 13 cm)

Answer 2

infection
portal hypertension/cirrhosis
AIDS

Question 3

Causes of MODERATE splenomegaly
(over 13cm)

Answer 3

leukemia
lymphoma
infectious mono

Question 4

Causes of MASSIVE splenomegaly
(way over 13)

Answer 4

Lymphomatous invovlement
mets
hematomas

Question 5

normal spleen measures

Answer 5

L - 8-13cm
H - 7cm
W - 5cm

Question 6

normal texture of spleen

Answer 6

homogeneous, smooth
correct direction of blood flow

Question 7

Types of splenic congestion

Answer 7

1. Acute
2. Chronic

Question 8

most common cause of splenic congestions

Answer 8

cirrhosis of the liver
portal vein hypertension/thrombosis

Question 9

other cause of splenic congestion

Answer 9

sickle cell crisis
cystic fibrosis
heart failure

Question 10

What are the 3 storage diseases

Answer 10

Amyloidosis
Gaucher’s Disease
Niemann-Pick Disease

Question 11

What is Amyloidosis?

Answer 11

2 types - nodular and diffuse

nodular: walls of arteries
diffues: actual red pulp/splenic tissue. Presents with splenomegaly

Question 12

What is Gaucher’s Disease

Answer 12

50% patients are younger than 8 years of age

bone pain and skin pigmentation
splenomegaly, heterogeneous, well-defined hypoechoic lesions