Patho exam 3 (ch 21-25) Flashcards
Upper airway structures
nasopharynx, oropharynx, laryngopharynx
Lower airway structures
larynx, trachea, bronchi, bronchopulmonary segments, terminal bronchioles, alveoli
Type I alveolar cells
epithelial structural cells
Type I alveolar cells
epithelial structural cells
type II alveolar cells
produce surfactant
surfactant
phospholipid that can lower surface tension and facilitate gas exchange
alveolar macrophage
phagocytize foreign particles damaged by smoking and inhalation of silica
what does the autonomic nervous system control
bronchi and bronchiole muscles
parasympathetic stimulation
mediated by acetylcholine leads to constriction of muscle
sympathetic stimulation
leads to relaxation of the smooth muscle
airway resistance
relationship between pressure and flow
airway resistance is influenced by
airway radius and pattern of gas flow
factors that decrease airway radius
mucus, bronchospasm, stress, pulmonary deconditioning, age
lung compliance
lung expandability and ease of lung inflation
–> provides estimate of airway resistance and elasticity of lung
why does lung compliance decrease?
increase in chest wall rigidity
reduced mobility of the ribs
partial contraction of inspiratory muscles
loss of elastic fibers in the lung
hypoventilation
air delivered to alveoli is insufficient to provide O2 and remove CO2
hypoventilation results in an increase of
pulmonary CO2
causes of hypoventilation
Morphine Barbiturates Obesity myasthenia gravis obstructive sleep apnea chest wall damage paralysis of respiratory muscles surgery of the thorax or abdomen
hyperventilation
increase in air entering alveoli leads to decreased CO2
3 important factors of pulmonary disorders
- inflammation
- edema
- excess mucous production
obstruction
small airway + resistance to expiration
increase resistance to airflow