Patho-ch2 Flashcards
devoted to the study of the structural, chemical, and functional changes in cells, tissues, and organs that underlie disease
Pathology
concerned with the common reactions of cells and tissues to injurious stimuli
General pathology
Examines alterations and underlying mechanisms in organ specific diseases such as ischemic heart disease
Systemic pathology
Four aspects of a disease process: give their definition.
- Etiology- cause
- Pathogenesis- biochemical and molecular mechanisms of its development
- Morphologic changes- structural alterations induced in the cells and organs of the body
- Clinical manifestations - functional consequences of these changes
Two classes of etiology
Genetic - inherited
Acquired - e.g., infectious, nutritional, chemical, physical
Symptoms and signs of disease
Clinical manifestations
Clinical course and outcome of disease
Progress
Cell’steady state
Homeostasis
reversible functional and structural responses to changes in physiologic state
Adaptations
NIS: Altered physiologic stimuli; some nonlethal injurious stimuli
CR:?
Cellular adaptations
NIS: Increased demand, increased stimulation (e.g., by growth factors, hormones)
CR: ?
Hypertrophy/ hyperplasia
NIS: Decreased nutrients, decreased stimulation
CR: ?
Atrophy
NIS: Chronic irritation (physical or chemical), reversible change in which one differentiated cell type (epithelial or mesenchymal) is replaced by another cell type
CR: ?
Metaplasia
NIS: Reduced oxygen supply; chemical injury; microbial infection
CR: ?
Cell injury
NIS: Acute and transient
CR: ?
Acute reversible injury, cellular swelling fatty change
NIS: Progressive and severe (including DNA damage)
CR: ?
Irreversible injury- cell death. Necrosis apoptosis
NIS: Metabolic alterations, genetic or acquired; chronic injury
CR: ?
Intracellular accumulations, calcification
NIS: Cumulative sublethal injury over long life span
CR: ?
Cellular aging
Nutrient deprivation triggers an adaptive cellular response called_______ and may also culminate in cell death.
Autophagy
This is stimulated by estrogenic hormones acting on smooth muscle through estrogen receptors, eventually resulting in increased synthesis of smooth muscle proteins and an increase in cell size.
Uterine hypertrophy
associated with increased atrial natriuretic factor gene expression
Cardiac hypertrophy
peptide hormone that causes salt secretion by the kidney, decreases blood volume and pressure, and therefore serves to reduce hemodynamic load.
Atrial natriuretic factor (ANF)
Occurs when there is a need to increase functional capacity of hormone sensitive organs; when there is need for compensatory increase after damage or resection
Physiologic hyperplasia
caused by excessive or inappropriate actions of hormones or growth factors acting on target cells.
Pathologic hyperplasia
Type of atrophy common during normal development
Physiologic atrophy
Type of atrophy, has several causes and it can be local or generalized
Pathologic atrophy
Enumerate the common causes of pathologic atrophy.
- Decreased workload (atrophy of disuse)
- Loss of innervation ( deneevation atrophy )
- Decreased blood supply
- Inadequate nutrition
- Loss of endocrine stimulation
- Pressure
AKA Profound protein-calorie malnutrition
Marasmus
brain and sometimes the heart may undergo progressive atrophy, mainly because of reduced blood supply as a result of atherosclerosis called_______
Senile atrophy
The most common epithelial metaplasia
Columnar to squamous
formation of cartilage, bone, or adipose tissue (mesenchymal tissues) in tissues that normally do not contain these elements
Connective tissue metaplasia
A direct link between transcription factor dysregulation and metaplasia is seen with _____________ deficiency or excess, both of which may cause metaplasia
vitamin A (retinoic acid)
Hallmarks of reversible injury
reduced oxidative phosphorylation with resultant depletion of energy stores (ATP), cellular swelling caused by changes in ion concentrations and water influx, intracellular organelles, such as mitochondria and the cytoskeleton, may show alterations.
a form of cell death that is characterized by nuclear dissolution, fragmentation of the cell without complete loss of membrane integrity, and rapid removal of the cellular debris AKA “programmed cell death”.
Apoptosis
“accidental” and unregulated form of cell death resulting from damage to cell membranes and loss of ion homeostasis
Necrosis
deficiency of oxygen, which causes cell injury by reducing aerobic oxidative respiration
Hypoxia
Enumerate the causes of cell injury
- Oxygen deprivation
- Physical agents
- Chemical agents and drugs
- infectious agents
- immunologic reactions
- genetic derangements
- nutritional imbalances
What are the two features of reversible injury recognized under light microscope?
Cellular swelling and fatty change
cells are incapable of maintaining ionic and fluid homeostasis, result of failure of energy-dependent ion pumps in the plasma membrane
Cellular swelling
Occurs in hypoxic injury and various forms of toxic or metabolic injury and manifested by the appearance of lipid vacuoles in the cytoplasm.
Fatty change
first manifestation of almost all forms of injury to cells
Cellular swelling
Ultrastructural changes of reversible injury
- Plasma membrane alterations
- mitochondrial changes
- dilation of ER
- nuclear alterations
form of necrosis in which the architecture of dead tissues is preserved for a span of at least some days; firm texture
Coagulative necrosis
localized area of coagulative necrosis
Infarct
characterized by digestion of the dead cells, resulting in transformation of the tissue into a liquid viscous mass
Liquefactive necrosis
A necrotic material that is frequently creamy yellow because of the presence of dead leukocytes
Pus
Not a specific pattern of cell death, usually involves lower leg that has lost its blood supply
Gangrenous necrosis
Superimposed bacterial infexn, more liquefactive because of the action of degradative enzymes and leukocytes
Wet gangrene