Patho-5-SLE Clinical Pathology

Question 1

Epidemiology of SLE

Answer 1

• prevalence influenced by age, gender, race & genetics
  
  • age peak 14-45y
  • Black > White
  • F > M (10:1)
  • HLA-DR3 association, family hx
• severity M = F

Question 2

Define SLE

Answer 2

heterogeneous autoimmune disease, of complex pathogenesis & protean clinical manifestations characterised also by immunological criterion including auto-Ab production against cell nuclei