Pathies Flashcards
Some normocytic and chromic / hemolytic anemia
Ss
F
Alpha
Gamma
Due to deoxyhgb formation
SS
Hgb insolubility
changes of hp
Rbc deformability
Electrophoretic mobility
Char by sickle cell
Ss
Drepanocyte
Immunity to malaria (p. falciparum)
Ss and as
Polychromasia of ss due to
High retic
Both globin chain
Homo
Washington monument like crystals (red)
Cc
Microcytic hypochromic
Thalassemia
Primary poikilocytosis
Target or codo
Sickle gene and c gene
Sc
A2
Alpha
Delta
Inclusion bodies in ss
Sickle Target Howell Nrbc Pappenheimer
Less sever than hgb s but more severe than c
Sc
No a1 with 90 f
Major homo cooleys
Chon of ss
High bili
Low haptoglobin
Pos for hgb solubility test
As
Sc
Bar of gold crystal
Sc crystal
Due to inc response of bm to hemolytic anemia
Vaso occlusive crisis
Mild anemia w microcyte and target
Homo hgb e
A1 dec
A2 inc
Beta minor
Unstable hgb presence of heinz bods and rigid rbc in spleen
Hgb h
Dec rate of synthesis of globin
Thalassemia
No a and b prod
Major or severe
High bili
Mhcool
All 4 alpha genes are deleted
Major alpha
Cannot carry h20
Bart’s hgb
Alpha major
A1
Alpha
Beta
Sufficient amt of a and b
Minor or mild
Major or homozygous aka
Cooley’s
Prod sufficient amt B-globin chain
Minor beta
4 beta chain
Hgb h
No or dec 2 beta
Major homo cooleys
Excess alpha
Major homo cooleys
Hp due to
Aa sub
Inclusion bods in major homo cooleys
Heinz
Destroyed by spleen and bm
Heinz
One alpha gene deleted
Silent carrier
Sign synp of major homo t
Hepatospleen
Face bone
Iron overload
High rbc ct and target cells
Minor alpha
Major alpha
Hydrops fetalis
Rbc in major homo cooleys
Target
Tear
Dec alpha chain
Excess beta chain
Hgb h
No normal hgb prod
Major alpha
Inclusions in major homo cooley
Pappen Nrbc Basoph stipp Howel Heinz
6% barts hgb in newborn
Minor alpha
Increase 5 serum iron
Makor hc
80% bart’s hgb
Alpha major
Age symptoms appear in major t
6 mon
3 alpha genes deleted
Hgb h
4 gamma
BArts hgb
Eryth become rigid and trapped in capillaries
Ss
Kidney failure
Joint swelling
Hyposplenism
Ss
2 alpha genes deleted
Minor alpha
One globin
Asymptomatic
Hetero
Mild anemia
Cc
Pos for target cell
Cc
Sc
Tissue necrosis
Ss