Path WBC/RBC Flashcards
Which of the following is INCORRECT about erythropoietin?
Polycythemia vera increases erythropoietin
Renal carcinoma can produce erythropoietin
fatty liver disease also does this
Hypoxia + high altitude stimulates erythropoietin production
Polycythemia vera increases erythropoietin
which of the following statements about reticulocytes is FALSE?
normal is 10%
Bone marrow response to anemia
Counts should be corrected for the anemia
High retic count is 10%
Inadequate retic response implies that the marrow is aplastic or dysplastic
normal is 10%
Which of the following is NOT part of a complete blood count?
leukocyte alkaline phosphatase (LAP)
Which of the following statements on hemoglobin F is INCORRECT?
- Shifts oxygen curve to the right
- oxygen more readily and thus less oxygen is unloaded
- Should be replaced by hemoglobin a by 97%
- Unconjugated bilirubin from the breakdown of fetal red cells
- Hemoglobin F gets broken down by splenic histiocytes thus physiologic jaundice
Shifts oxygen curve to the right
which of the following is NOT a red cell inclusion?
o Calgary A bodies o Holly jolly bodies o Basophilic stippling o Heinz bodies o Pathoheimic bodies
Calgary A bodies
Which of the following are associated with microcytic anemias?
MCV <80 Iron deficiency anemia Chronic disease Sideroblastic anemia all of the above
all of the above
False about Kolinicha?
o almost never seen in iron deficient anemia
o finger nails become thin, brittle, and concave
o Spoon shaped
o Distal half
almost never seen in iron deficient anemia
: Which of the following are features of iron deficiency?
o all of the above
o Serum iron is decreased
o total iron binding capacity is elevated
o saturation
A: all of the above
Which of the following are CORRECT about anemia of chronic disease?
o all of the above
o Common
o Last longer than 1-2 months
o 25% of cases only chronic diseases present in the pt such as CHF
o usually anemia is mild to moderate with a hematocrit >25%
o serum iron is reduced
o iron binding capacity is reduced
o percent saturation may be
all of the above
Which of the following statements regarding bthal is CORRECT?
o all of the above
o B thal includes severe, moderate, and mild, major, intermediate, minor
o B thal major is a homozygous disease
o B thal is caused by inheritance of two b thal alleles resulting in little to no b chain
o A chain synthesis remains normal in b thal
all of the above
which of the following statements regarding macrocytic anemia is INCORRECT?
cause of macrocytic anemia in alcoholics is a deficiency of B12 and folate
the following are expected lab results in hemolytic anemia EXCEPT? o haptoglobin increases o Polychromatic philia o Indirect bil increases o Serum LDH increases o Retic > 3
haptoglobin increases
Spherocytes can be seen in?
everywhere
Teardrop cells seen in? o all of the above o myelofibrosis o Hemolysis o Megaloblastic anemia o Cancers of BM: BM infiltration, mylocystic syndrome, metastases
all of the above
Which of the following statements about parvovirus B19 is CORRECT?
o all of the above
o Can cause red cell aplasia
o Bone marrow aspirate smears usually show giant erythroblasts
o The erythroblasts on BM show intranuclear viral inclusion
o The erythroid inclusion show blasty intranuclear inclusions called Lantern cells
all of the above
Which of the following is NOT a myledysplastic syndrome?
o Chronic neutrophilic leukemia
o Refractory anemia
o Refractory anemia of ring sideroblast
o Refractory cytopenia with multilineage dysplasia (RCMD)
Chronic neutrophilic leukemia
: Which of the following statement regarding systemic mastocytosis are CORRECT?
o all of the above
o You should see dense infiltrates of mast cells in the bone marrow
o You can see extra cutaneous organ involvement >15% mast cells
o Mast cells stain with
o A minor criteria of mast cells seen in bone marrow >25%
all of the above
which of the following statement regarding primary myelofibrosis is NOT correct?
o 75% of cases transformed into AML
o Mean age is 60 yrs
o Rarely occurs in kids
o Mylofibrosis is a clonal stem cell defect with pan myelopathy
o Can see extramedullary hematopoiesis in lymph node
o Fibrosis is due to neoplastic megs releasing growth factor
75% of cases transformed into AML
• Which of the following statements regarding essential thrombocytopenia is false?
o JAK2 mutation is rare
which of the following of polycythemia veria is INCORRECT?
o without treatment patients live 5-10 years
o Jack2 mutation in 97%
o Must differentiation pvera for reactive process
o Pvera erythropoietin levels are decreased and o2 stats are normal
o Can be due to lung disease
without treatment patients live 5-10 years
All of the following of myeloproliferative disorders EXCEPT? o multiple mylenoma o Chronic myelogenous leukemia o Polycypenia vera o Essential thrombocythemia o Primary myelofibrosis
multiple mylenoma
: Which of the following statements regarding mycosis fungoides is correct
o all of the above
o Single most important prognostic factor is clinical stage
o Limited diseases has excellent prognosis, survival similar to normal population
o Adverse prognostic parameters include: disseminated disease, >60 yrs, high LDH
o 25% of peripheral involvement of blood is called Szery syndrome
all of the above
Which of the following statements about mycosis fungoides is INCORRECT?
o cutaneous T cell lymphoma is an extremely rare primary cutaneous lymphoma
o CTL often misdiagnoses as psoriasis
o Multiple skin lesions that progress from sclaes to plaques
cutaneous T cell lymphoma is an extremely rare primary cutaneous lymphoma
\: The diagnostic criteria for chronic lymphocytic leukemia (CLL), which of the following is true? o all of the above o Absolute lymphocytosis > 5% o >30% lymphocytosis in BM o monoclonal B cells with CD5 + CD20 o peripheral blood smear of smudge cells
all of the above
Which of the following statements about T cell acute lymphoblastic leukemia (TALL) is correct? o all of the above o Expresses CD2 + CD28 o Blasts are CD10- o Seen in teenagers o Often seen with mediastinal mass
all of the above
which of the following statements about b cell acute lymphoblastic leukemia (B cell ALL)
o all of the above
o Good prognosis with translocation 12,21
o Translocation 12, 21 often seen in kids
o Poor prognosis with 9,22
• Philadelphia chromosome
o More common in adults
all of the above
Which is false about ALL
B all has a poor response to chemo
which of the following statement about ALL are correct?
o all of the above
o Malignant proliferation of lymphocytes
o Most in kids
o When associated with DS, can happen under the age of 5
o Lymphoblasts stain with TDT
o Absent in myeloblasts
all of the above
which of the following are unfavorable genetic abnormalities in AML
deletion of 5q-
• Q: Which of the following WHO classifications for myelogenous leukemia are INCORRECT?
o all of the above
o Acute myeloid leukemia with recurrent genetic abnormalities
o Acute myeloid leukemia with multiple lineage dysplasia
o AML with myelodysplastic syndrome
o Therapy related AML
o AML not otherwise classified
all of the above
Which of the following are NOT unfavorable prognostics for AML? o young kids who respond to chemotherapy o Patients under the age of 2 o Marked leukocytosis o History of myelodisplasia o FLT3
young kids who respond to chemotherapy
Which of the following are true about AML
o all of the above
o Malignant proliferation of immature cells
o CD34+
o Antimyloperoxidase stains in myeloblasts
o Aggregates of MPO are Auer Rods
all of the above
causes of monocytosis
- Chronic inflammation
- Autoimmune
- Infection
- Malignancy
causes of leukocytosis
- Bacterial infections
- Tissue necrosis
- Release of marginated cells from BM
- High cortisol states
Haptoglobin
does NOT increase in hemolytic anemia
