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Path- WBC Neoplasias Gomez Flashcards

1
Q

proliferation centers

A

Small lymphocytic lymphoma

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2
Q

prolymphocyte

A

small lymphocytic lymphoma

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3
Q

smudge cells

A

chronic lymphocytic leukemia

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4
Q

peripheral T-cell lymphoma, unspecified

clinical features

A

mainly older adults; usually presents with lymphadenopathy; aggressive

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5
Q

T-cell neoplasm in children

A

anaplastic large-cell lymphoma

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6
Q

anaplastic large-cell lymphoma, genotype

A

ALK

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7
Q

anaplastic large-cell lymphoma, morphology finding

A

hallmark cells (horseshoe/kidney shaped)

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8
Q

ALK+ vs ALK-

A 
ALK+ = can be treated, better prognosis. usually seen in children. 
ALK- = cannot be easily treated, worse prognosis, usually seen in older pt's
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9
Q

adult t-cell leukemia/lymphoma, genotype

A

HTLV-1

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10
Q

adult t-cell leukemia/lymphoma, cell marker

A

CD25, CD4

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11
Q

adult t-cell leukemia/lymphoma, clinical features

A 
hypercalcemia 
cutaneous lesions 
marrow involvement 
pt's from Japan, West Africa, Caribbean 
aggressive
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12
Q

adult t-cell leukemia/lymphoma, morphology finding

A

cloverleaf nuclei

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13
Q

mycosis fungoides aka

A

Sézary syndrome

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14
Q

mycosis fungoides, clinical features

A

adults with cutaneous patches, plaques, nodules, or generalized erythema
indolent

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15
Q

Sezary syndrome

A

generalized exfoliative erythroderma

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16
Q

mycosis fungoides, morphologic finding

A

cerebriform nuclei

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17
Q

large granular lymphocytic leukemia, types

A

Cytotoxic T cell: indolent

NK cell: aggressive

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18
Q

large granular lymphocytic leukemia, associated syndrome

A

Felty syndrome

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19
Q

Felty syndrome

A

RA
splenomegaly
neutropenia

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20
Q

large granular lymphocytic leukemia, clinical features

A

adult pt with splenomegaly, neutropenia, anemia, sometimes accompanied by autoimmune disease

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21
Q

extranodal NK/T-cell lymphoma, genotype

A

EBV-associated

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22
Q

extranodal NK/T-cell lymphoma, cell marker

A

CD56

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23
Q

extranodal NK/T-cell lymphoma, clinical features

A 
Adults with destructive extra nodal masses, most commonly sinonasal
Aggressive. 
Midline lesions. 
Poor response to chemotherapy. 
Small vessel invasion.
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24
Q

MCC of acute leukemia associated with Down Syndrome

A

acute lymphoblastic leukemia

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25
Q

lymphoblastic neoplasms, special stains

A

PAS/Myeloperoxidase

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26
Q

B-cell acute lymphoblastic leukemia/lymphoma, genotype

A

chromosomal translocations (hyperdploidy)
t(12;21) involving RUNX1 and ETV6
t(9,22) BCR-ABL1

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27
Q

B-cell acute lymphoblastic leukemia/lymphoma, clinical features

A

predominantly children –> epistaxis and bleeding gums
sx relating to marrow replacement and pancytopenia
aggressive

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28
Q

B-cell acute lymphoblastic leukemia/lymphoma, cell markers

A

CD19, PAX5, sIg -, TdT +

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29
Q

B-cell acute lymphoblastic leukemia/lymphoma, prognosis

A

good for peds

bad for adults

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30
Q

T-cell acute lymphoblastic leukemia/lymphoma, genotype

A

chromosomal translocations

NOTCH1 in 70%

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31
Q

T-cell acute lymphoblastic leukemia/lymphoma, clinical features

A

predominantly adolescent males
thymic mass
variable bone marrow involvement
aggressive

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32
Q

T-cell acute lymphoblastic leukemia/lymphoma, cell markers

A

CD1, 2, 5, 7, TdT+

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33
Q

Hodgkin lymphoma, most common subtype

A

nodular sclerosis

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34
Q

nodular sclerosis, morphologic finding

A

lacunar cells

35
Q

nodular sclerosis, genotype

36
Q

nodular sclerosis, cell markers

A

PAX5, CD15, CD30

37
Q

nodular sclerosis, epidemiology

A

young patients, M=F

38
Q

most common form of Hodgkin lymphoma in patients >50y/o

A

mixed cellularity

39
Q

mixed cellularity Hodgkin lymphoma, cell markers

A

CD15, PAX5, CD30

40
Q

mixed cellularity Hodgkin lymphoma, genotype

41
Q

nodular sclerosis, clinical features

A

usually stage I or II disease
frequent mediastinal involvement
young pt

42
Q

mixed cellularity, clinical features

A

> 50% present as stage III or IV disease

M>F

43
Q

Hodgkin Lymphomas, list subtypes

A

Classic

  • Nodular sclerosis
  • Mixed cellularity
  • Lymphocyte rich
  • Lymphocyte depletion

Lymphocyte predominance

44
Q

lymphocyte predominance Hodgkin lymphoma, morphologic finding

A

L&H (popcorn cell)

45
Q

lymphocyte predominance Hodgkin lymphoma, cell markers

A 
CD20+ 
CD15- 
CD30-
EBV- 
BCL6+
46
Q

lymphocyte predominance Hodgkin lymphoma, clinical features

A

young males
cervical or axillary lymphadenopathy
mediastinal

47
Q

Hodgkin lymphoma of developing countries and HIV-infected individuals

A

Lymphocyte depletion

48
Q

Diagnostic morphologic finding of Hodgkin lymphomas

A

Reed sternburg cells

49
Q

SLL/CLL genotype

A

Trisomy 13q = good prognosis

IGVH mutation = Zap70(-), CD38(-) = good prognosis

50
Q

SLL/CLL clinical features

A

older pt
bone marrow, lymph node, spleen, and liver disease
indolent

51
Q

follicular lymphoma, genotype

A

t(14;18) creating BCL2-IgH fusion gene

52
Q

follicular lymphoma, cell of origin

A

centroblasts and centrocytes in the germinal center

53
Q

follicular lymphoma, clinical features

A

older pt with generalized lymphadenopathy and marrow involvement
indolent (MCC indolent lymphoma)
low-grade splenic involvement

54
Q

follicular lymphoma, cell markers

A

CD19, 20, 10, sIg, BCL6

55
Q

diffuse large b-cell lymphoma, genotype

A

diverse chromosomal rearragements
BCL6
BCL2
c-MYC

56
Q

diffuse large b-cell lymphoma, clinical features

A 
all ages, but most common in adults 
often appears as a rapidly growing mass 
30% extranodal 
aggressive 
high-grade splenic involvement
57
Q

diffuse large b-cell lymphoma, types

A
  1. Mediastinal (young females, involving viscera and CNS)
  2. Immunodeficiency (HIV pt’s, etc)
  3. Body cavity/Primary effusion (KSHV/HHV8 pt’s with HIV)
58
Q

Auer rods

A

acute myelogenous leukemia

59
Q

acute promyelocytic leukemia, genotype

A

t(15;17)
Retinoic acid receptor α (RARA) gene on chromosome 17
PML gene on chromosome 15
PML/RARA fusion proteins block differentiation at promyelocyte

60
Q

CD34 - marker for…

A

multipotent stem cells

61
Q

CD64 - marker for…

A

mature myeloid cells

62
Q

CD33 - marker for…

A

immature myeloid cells

63
Q

CD15 - marker for…

A

more mature myeloid cells

64
Q

bevacizumab’s antigen

65
Q

cetuximab’s antigen

66
Q

rituximab’s antigen

67
Q

trastuzumab’s antigen

68
Q

t(15;17)

A

APL, PML-RARA fusion gene

69
Q

inv(16)

A

AML M4

Myelocytic and monocytic differentiation; abnormal eosinophilic precursors in marrow with abnormal basophilic granules

70
Q

APL treatment

A

all trans retinoic acid

71
Q

Unique complication of APL

72
Q

Most common myelocytic leukemia in Down Syndrome

A

acute megakaryoblastic leukemia

73
Q

Pseudo-Pelger-Hüet cells

A

Myelodysplastic syndrome

Neutrophils with two nuclear lobes & abnormal granules

74
Q

CML, most common translocation

75
Q

Ringed sideroblasts

A

Myelodysplastic syndrome

76
Q

polycythemia vera mutation

A

JAK2 V617F (in 95% of PV patients!)

77
Q

treatment for CML

78
Q

essential thrombocythemia mutation

79
Q

leukoerythroblastosis in blood smear is seen with…

A

primary myelofibrosis

80
Q

primary myelofibrosis mutation

81
Q

dacryocytes

A

primary myelofibrosis

82
Q

Langerhans cell Histiocytosis, morphologic finding

A

Birbeck granules

83
Q

Langerhans cell histiocytosis AKA

A

eosinophilic granuloma

84
Q

Hand-Schuller-Christian triad

A

calvarial bone defects
diabetes insipidus
exophthalmos

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