Path (from B&B) Flashcards
type I hypersensitivity reactions
Anaphylactic
-allergen activates B-lymphocytes and IgE
- HISTAMINE is the primary mediator
- these responses are FIRST and FAST
Type II hypersensitivity reactions
Cytotoxic
- antibodies against antigens absorbed on carious tissue components (cell surfaces)
- IgM and IgG
- Rh diseases
- rheumatic fever
type III hypersensitivity reactions
Immune-complex mediated
- Ag/Ab complexes
- activates the compliment response
*SLE
Type IV hypersensitivity reactions
Delayed or cell mediated
-T lymphocytes encouter a pathagen an release leukokinin leading to a macrophage activation
disease affects multiple systems and includes butterfly (malar) rash
SLE
*90% have joint pain
destruction to the articular cartilage
most often in women
RHEUMATOID arthritis
disease marked by dry mouth, dry eyes, and arthritis
DECREASED exocrine functions
sjogren’s syndrome
disease induced by herpes simplex virus
-shows BULL’S EYES leasions
erythem multiforme
blistering of the skin that is a result of IgG antibodies directed against desmosomes
pemphigus vulgaris
blistering of the skin directed against HEMIdesmosomesal proteins
bullous pemphigoid
T cell mediated autoimmune disease with wickham’s striae
oral lichen planus
urate crystals in response to inc uric acid levels
gout
HIV is what type of virus/
RNA
karposi’s sarcoma
HIV/AIDS
hairy leukoplakia
HIV/AIDS
tongue may exhibit herpetic leasions and ulcers
HIV/AIDS
gram + infection with honey colored crusted lesions
Impetigo
recurrent oral aphthous ulcers
bechet’s disease
occurs with asymmetry, border irregularity, color differences, large diameter, and enlarging
malinant melanoma
*more common in women
type of melanoma that is LEAST LIKELY to metastisize
basal cell carcinoma
malignancy of the stratum spinosum and arises form actinic keratosis
squamous cell carcinoma
most common chromosomal disorder (extra 21rst)
that includes mental retardation, prominent epicanthal folds, congenital cataracts, glaucoma, and strabismus
down’s syndorme
extra X chromosome that presents with testicular atrophy, long extremities, gyneomastia, female hair distribution, and hypogonadism
klienfelter’s syndrome
absent X chromosome that presents with short stature, dysgenesis, webbing of the neck, and coarctation of the aorta
turner’s syndrome
associated with hamartomatous polyps in the GI tract and pigmented mucocutaneous lesions
*hyperpigmentation
peutz-jegher’s syndrome
classic triad of:
- cafe au lait spots
- neurogibromas
- lisch nodules
neurofibromatosis
vonrecklinghausens disease
autosomal dominant disorder associated with chorea and demetia
huntington’s disease
associated with gardner’s syndrome and 100% of these pts will get colon cancer
Familial adenomatous polyposis
in SS anemia, what is teh amino acid exchange
valine substituted for glutamic acid
a disease that is a destruction of the nervous system found commonly in jews
tay-sachs disease
associated with abnormal collagen synthesis and includes:
- blue sclera
- malocclusion
- malformations of the teeth
osteogenesis imperfecta (brittle bone disease)
most common type of anemia that includes:
- GI blood loss
- malabsorption
- treated with oral iron
iron deficieny
pancytopenia characterized by:
- severe anemia
- neutropenia
- thrombocytopenia
aplastic anemia
caused by pernicious anemia which is autoantibodies against parietal cells
vitamin B12 deficiency
dietary deficiency that is especially common in alcoholics
folic acid deficiency
malignant clone of plasma cells in the bone marrow which causes skeletal bone destruction
Multiple myeloma
associated with reed sternberg cells and is associated with EBV
hodgkins lymphoma
associated with enlarged lymph nodes and GI tumors
non-hodgkins lymphoma