Path Flashcards
Coagulation:
infarction
myocaridal infarction
Liquefaction
CNS
Caseous
TB
Enzymatic
Pancreas
Fatty
Liver
precurser to nutmeg liver
Zenker
aka Waxy
Wallerain
peripheral nerves
Cloudy swelling
albuminous
which of the following involves the injury of the membrane
swelling of cells due to injury of the mebrane
affecting the ionic transfer
Development changes
Agenesis
absence of a organ usually a paired organ
Development changes
Hupoplasia
organ usually smaller than the normal organ and usually defective
Development changes
Aplasia
lack of devlupment
remnants of the organ are there but not fully develuped
Disturbance of growth
Atrophy
decrease in size (disuse)
Disturbance of growth
Hypertrophy
increase in size (muscular exercise)
Disturbance of growth
Hyperplasia
increase in number of cells ( pregnants uterus)
Disturbance of growth
Metapalsia
changes from one cell type to another
Disturbance of growth
Lungs of a smoker?
PSeudostrficied ciliated cominlar changes to stratified squamous in a smoker
Disturbance of growth
Dysplasia
disorganized
change in size , shape , or function of a cell
(precede cancer but is reversible)
Disturbance of growth
Anaplasia
complete disorganization of a cell ( cancer)
TYPES~O:F CANCER~:
Condma
benign cartilaginous tumor
TYPES~O:F CANCER~:
Carcinoma
cancer of the epithelial tissue usually spread by the route of the lymphatic system
TYPES~O:F CANCER~:
Sarcoma
cancer of the connective tissue usually spread by blood
TYPES~O:F CANCER~:
Carcinoma in siti
cancers that has NOT invaded the
“basement membrane”
Bacteremia
bacteria in the blood
Septicemia
pathogens or toxins in the blood
Anoxia
absence of oxygen
Hypoxia
deficiency of oxygen
Thrombus
platelet deposition
Clot:
fibrinogen into fibrin via thromboplastin
Embolus
foreign body in the blood that travels
Diapedesis:
nuetrophils and monocytes squeeze through the walls of blood vessels
Chemotaxis
Movement of WBC against the gradient of a avrety of tissue damage products
Phagocytosis
accomplished through neurtophils and macrophages
Pavmenting
adhesion of leukocytes the the endothelial lining of blood vessels
Metstatic calcficiation
calcification into normal tissue
as a result of too much vitmnin D
as a result calcium deposits
Dystophic calficicantion
calcification of dmaged tissue
athtloma
PNEUMOCONIOSIS:
Deposition of particles in the lung
Silicosis :
silica (rocks of glass) in sandblasting
seen in sandblaster quarry rock loans
Asbestosis
asbestos leads to mesothelioma –> Is malignant
Siderosis
iron dust
Byssinosis:
cotton dust called Brown lung
Berylliosis
Fibers- aircraft manufacturing
Arithracosis
Black lung disease from Miners (coal)
Toxicdymycosis
san jaunin valley fever
Histoplasmosis:
Missisippi OH fever
Syphilis
congenital
Stages
- Hutchinson’s teeth- notched permanent incisors
- Rhagades - fissures and cracks at the end of the mouth
3> saddle nose deformity - bridge of nose deformity
- Sabre blade tibia
- Interstitial kerrititis produces visual changes.
This also can be associated with deafness.
Syphilis
Acquired
4 Stages of Syphilis
Stage 1: Primary Stages
hard, singular painless nodule on perineum
Known as a Shanke
Syphilis
Acquired
4 Stages of Syphilis
Stage 2: Secondary Stages
maculopapular rash and condylomata lata (flat
warts on the vulva
Syphilis
Acquired
4 Stages of Syphilis
Stage 3 : Latency
Mayor may not have symptoms
Syphilis
Acquired
4 Stages of Syphilis
Stage 4: Teritary
Neuro syphilis
Syphilis
Acquired
4 Stages of Syphilis
Stage 2: Secondary Stages
maculopapular rash and condylomata lata (flat
warts on the vulva
Syphilis
Acquired
4 Stages of Syphilis
Stage 3 : Latency
Mayor may not have symptoms
Syphilis
Acquired
4 Stages of Syphilis
Stage 4: Teritary
Tabes dorsalis
aortic anerrism
argyl roberson pupil - prosotutes pupil
Gummas neucrosis in body tissue
Chanceroid
soft chanceroid painful caused by-Hemophilus ducrey
Gonorrhea:
gram negative diploccus causing burnign in the urine with
yellow green pus in the urine
can produce arthtits in the knee
Lymphogranuloma venereum
chlamydia is the organism
produces rectal strictures
Dx: frei test
Ghnorrea
MC PID
Granuloma inguinae
red nodules in ingual area
Trichonomas
purulents vaginal dischagre – green frothy protzoan
GArdenalla vaginallis
foul smelling discharge. Clue cells
Dysphagia
trouble swallowing
Sliding hiatal hernia
due to anatomicallyshortened esophagus
Diverticula
outpouching in the intestine. Usually I :Lower left
quadrant of the abdomen
descending and sigmoid colon
volvulus:
Twisting of an organ
around the lungs axis
Intussusception
telescoping of intestine onto itself
Celiac disease
intolerance to gluten
on gluten free diet is how your
Crohns
regional ileitis - seen in young people
affects the distal colon
produces
skip lesions
Hirschbrung’s:
Congenital megacolon. Absence of the myenteric plexus
Ulcerative colities
Patholigcials intestianals changes ulcers, bloody diarhea
complications produce toxic megacolon
descending sigmid colon
Irritable bowel:
spastic colon, distention, pain, diarrhea . stress
related
Peutz Jegher’s:
Polyposis characterized by polyps in the entire
GI tract
Caplans sydrome
affect coal miners / nodules in lungs
Belke sydrome
RA with splenomegaly
Emohezema
alpha - anti - trypsin - disease - deficiency
Pagets
ostetis defromisn - producued thcickeing and defromity of the bone
MEN over <50
Cortical thickening
PAtholigical is the osteocalstic
Stills
a form of juvenile Rheumatoid arthritis
Parkinsons
aka paralysis agitans
problems with dopaminein th ebasal cell ganglia.
Inclusiosn bodies called LeWY bodies
PAtient has masked face
stopped posture
resting tremor
festinating gait (shufflinf gait )
Multiple Sclerosis
Demyelinizationand plaguing of the SC or brain
Charcot’s triad
scanning speech, intention tremor and nystagmus.
Characterized by exacerbations and remissions.
Charcot’s triad
scanning speech, intention tremor and nystagmus.
Characterized by exacerbations and remissions.
Myethesia Gravis
Formationof antibodiesthat block the ACH receptorsat the
myoneuraljunctionproducingexcess cholinesterase
thymic enlargement
causes progressiove weakness and fatigue
FIRST starts with the occular muscles - especially with fatigued
ALS
Lou Gherigs disease
Contical spinal tracts affects with no sensory loss
UMNL in lower limbs
LMNL in upper limbs
PLS
combined system disease
results in pernicious anemia
DUE to B12 anaemia
Synigomeleia
cyst formation
loss of pain and temperature
cape like distributions
Arnold Chiarii
congential brain stem through the foramen magnum
Huntington’s:
chorea
Heredity onset 30-50 basal ganglia ( of caudate nucleus ) affected
defiicnty of GABA
produces dementia and death
chromosoem #4 is afected
Alziemers
progressive serve atrophy of the cerebral cortex
ACH decrease
Fradreichs ataxia
lesions and sclerosis of the spinocerebaelar tract
Guilliene barr peylonephrirtis
Pyloneuritis of PNS.
seen follwoing immunizations and
producesan ascending paralysis.
Can be fatal~/~
If it affects the **Anterior horn)it producesI ***LMN If it
affects the brain stem, then cranial nerves are affected
and the breathing apparatus may be damaged
Korsakoff:
Alcoholic psychosis. Depletion of thiamine due
to severe alcoholism
Charcot Marie
Hereditary progressive peroneal muscle atrophy
Tooth aka
Peraneal mucosal atrophy
dushenes musclar dystropy of the claves usually boys
3-7
recessive linked gene
recessive linked gene
perineal and anterior tibialais msucles affected
Kwashiorkor
protein malnutrition
Marasmus
calorie malnutrition, includes protein
Wilson’s
Inborn error of copper metabolism. “keiser fleisher rings of the iris
diabetes insipidus
decrease due to a posterior pituitary
results in dehydration *****
Deisabetes melittus
decrease production of insulin of beta cells of the pancrease
(islet and langerhans )
productions of polydysia , polyuria , polyphagia
- usually myocardial infarct
- Renal failure
Duschenes
muscle replaced to fat
1st sign of diebetes
in the eyes neuovascularization
Genetic disorders:
Turners syndrome
45 XO
Female
short stature
webbed neck
lack female secondary sex characteristics
Genetic disorders:
Down sydrome
Trisomy 21 chromosome
Male or female
Mental retardation flat hypo plastic face
Sinuses crease of the palm
Genetic disorders:
Fragile X
Is the most common forma of mental retardation
involving a 2 X chromosomes and one or more Y chromosome
Genetic disorders:
Phenoketoneuria
cannot convert phenyalanine to tyrosine
due to a lack of phenyalanine hydrolase
***** retardation can be controlled by diet if caught early
Genetic disorders:
Von Gierke’s
lack of enzymes to break down glycogen
excessive amounts of glycognen found in the liver
Genetic disorders:
Tay Sach
increase gangliosides found in the brain (glycophinoilipid)
*** hexosaminidase deficiency
** Cherry spots in the macula
***Infant death
Genetic disorders:
Gauchers
excess glucocrebrocide in the brain , liver and spleen
Genetic disorders:
Krebbes
increased Galactocrebroside in white matter
Genetic disorders:
Neimons pick
abnormal increase in sphingomyelinase
decrease in shingomylinase
Genetic disorders:
Alkaptoneruia
accumulation of hemogensisits acid ,
blue black deposotus in the ears
Produces *** ochonochrosis which is clacification of the the discs of the spine
** Build up of tyrosine
Genetic disorders:
Duchenes MD
seen mostly in boys 3-7 years of age
produces hypertrophy in the calf muscles
** recessive linked gene /Waddling gait
INCREASE in CPK (mean the muscles are dying )
Genetic disorders:
Edwards syndrome
Trisomy 18
Genetic disorders:
Leukoplakia
white patches of muscosa that cant be scatched off
Genetic disorders:
Teratoma
tumors of all 3 layers
Genetic disorders:
Adenoma
tumor of the glandular tissue
Genetic disorders:
krukenbergs
cancer of the stomach
thats metastasizes to the ovary
Genetic disorders:
Wilsm
mixed tumor of the kidney in children
Genetic disorders:
Leioma
tumor of smooth muscle
fibroids in the uterus
Genetic disorders:
Rhabdomyoma
Tumor of striated muscle or heart muscle
Genetic disorders:
Osteosarcoma
Most common bone cancer in children
~Multiplemyeloma
most common malignancy in adults
Bence jones and routoe formation
Metastasis
most common tumor in the spine
Lipoma
fatty tumor
Hemagioma
benign tumor of the blood vessels
Xanthoma
Yellow tumor of connective tissue
Chondroma
bengin tumor of cartilage
Papilloma
associated with warts
HPV-16
Seminoma
cancer of the testies - most common
Virchow’s nodes
Enlarged supraclavicular lymph nodes due to
metastasis usually in the GI tract
WBC
Neutophils
60% increased in acute **bacterial~infections
*Acute inflamation
WBC
Lymphocytes
30% increased in viral conditions
*Chronic iinflamation
Monocytes
increase in chronic conditions
changes in phagocytes
Eosinophils
parasitesand allergies
*reduce anti histamines
Basophils
similar to mast cells … produce heparin and histamines
increase blood disorders
Mast produce the following
- Hsitmine
- Heparin
- Serotonin
- Badykinin
LYMPHOCYTES:
B
B. Transforms to a plasma cell
LYMPHOCYTES:
T
T. Matures in the thymus
- Helper: activates B
- Suppressor: decreases antibody production
- Killer: kills foreign agents EX: transplant rejection
IMMUNE COMPLEX:
Steps
- antigen enters - proceeds by macophages
- Pahgocytosed by macropahges aka antigen presenting cell by Cd4 cells
- Exposes antigen to B cells and T helper cells
- T cells make sure that B cells react
- Plasma cells make anitbodies forming the immune complex
Cancer cells can be destoryed by
CD8 cells
which are killer cells
HEART AND BLOOD VESSEL DISEASE:
Arteriosclerosis:
thickening, calcification and loss of elasticity
of the arterial walls
HEART AND BLOOD VESSEL DISEASE:
Atherosclerosis:
deposition of fatty plaques (atheroma)
This is a form of arteriosclerosis
EART AND BLOOD VESSEL DISEASE:
Monkeberg I s sclerosis
tunica media** of **medium sized arteries calcified
Aneurysm
berry
in the circle of Willis, subarachnoid hemorrhage
Aneurysm
Dissecting
longitudinal tearing away of the aorta
Abdominal aorta
can cause low back pain due to erosion of the
anterior vertebral body
Beuggers
thomboangitis obliterans
person who smokes heavily
Intermittent claudication
Lower extemity is affected
Raynaud’s
Vasospasm of the arteries
may be primary or secondary to other collagen diseases such as lupus
Found in the hands or feet producing a**** triphasic color change
FROM pallor to cyanosis and rubor *****
brought on by cold or emotion
Temporal Artetites
aka giant cell artetities
affects temporal arteries
Asocoated with long standing hypertension
Takayasu arteritis
aka pulseless disease
granulomatou sinflammation of theaortic arch
Congenital
Tetrology of Fallot
Likely to cause cyanosis
DRIP
Dextro rotation of the aorta
Rright ventricular hypertophy
Interventricular spetal defect
Pulmonic stenosis
Coarctationof the aorta
reverse normal BP
aorta narrowing of the lumen produces increased
blood pressure in the upper extremities and decreased blood
pressure in the lower extremities
B-lymphocyes incolved in
Hormonal immunity ( b -lymphocytes to cell immunity )
T cell in mediated
mediated immunity
BLOOD CELL DISORDERS
Hodgkin’s lymphoma:
Causes seriously enlarged lymph nodes. Produces a Pel
Epstein fever which comes and goes.
diagnosis based upon tissue biopsy and presence of the Reed Sternberg cell
BLOOD CELL DISORDERS
Non Hodgkin’s lymphoma:
Mostly seen in older people. No Reed Sternberg
~ cells. Symptoms same as Hodgkin’s, but more severe. Includes
Burkett Is Ivmph~ which is described by its “starry sky appearance
BLOOD CELL DISORDERS
Multiple myoloma
a leukemia of bone marrow. affects the plasma cells.
usually over 50
BLOOD CELL DISORDERS
Brutuons agammaglobulinemia:
a X linked hereditary disease
Decrease IgG
Decrease B cells
B cell defieiciency
BLOOD CELL DISORDERs
DiGeorges
a Tell cell defieicincy cause by
a hypoplasia of the Thalamus
Leukemia:
Acute lymphoblastic
ALL
ALL
seen in children
Leukemia
Chronic lymphocytic
CLL
older 75% over 60 increased mature -
lymphocytes
Leukemia
Acutcute meyeloblastic
(AML)
85% adult
can happen at any age
*worst prognosis
Leukemia
Chronic myelocytic:
(CML)
young adulthood, increased granulocytes
“Philadelphia chromosome”
30-40 years old
ANEMIA
lack or loss of RBC
ANEMIA
Loss:
Hemorrhage
Hemolytic Breakdown
Hemolytic breakdown of cells by some disease in the body such
as sickle cell anemia or malaria
ANEMIA
Loss:
Thalassemia Major:
AKA Cooley’s anemia
Homozygous Beta Thalasmsia
AKA medteranains thalasemia
ANEMIA
Loss:
Erythroblastosis fetalis
Rh- Mother, Rh+ Father, Rh+ baby
ANEMIA
Decreased productions of RBC
Nutritional
Iron Defieicent
most common
microcutic
hypochromic
- paler in color
ANEMIA
Decreased productions of RBC
pernicious:
due to lack of intrinsic factor
ANEMIA
Decreased productions of RBC
Folic acid
seen in pregnancy
ANEMIA
Decreased productions of RBC
B12
seen in vegetarians
ANEMIA
Decreased productions of RBC
Bone Marrow suppression
Decreased Rbc”s due to toxins or chemotherapy
ANEMIA
POLYCYTHEMIA: Increase in RBC”S
Can be in response to high altitudes or lung problems
Vera true pathological condition
ANEMIA
Thrombocytopenia
decreased platlets in the blood
megakarycytes
PROCESS OF COAGULATION:
- Injury leads to release of thromboplastin
- Leads to production of prothrombin to thrombin (acts as catalyst)
- Thromboplastin is thought to be releseaed by damaged cells
- Prothrombin is formed in the liver
- Fibrinogen is formed in the liver
Positive feedback: the more thrombin produced, the more fibrin is
produced
Which is a decrease in platelet rbc and wbc ?
pancytopenia
What type of anemia is it when there is a degneration of bone marrow?
Aplastic anemia
IMMUNOGLOBULINS:
IgA
Exocrine secretions, milk, tears and saliva
IMMUNOGLOBULINS:
IgD
Unknown
IMMUNOGLOBULINS:
IgE
Lines respiratory and intestinal tracts. Associated with allergies (increased eosinophils), asthma, Hay fever
IMMUNOGLOBULINS:
IgG:
Major antibody against virus, bacteria, toxins. Passes placenta
IMMUNOGLOBULINS:
IgM:
Early part of every immune response
HYPERSENSITIVITY REACTIONS:
Type I:
ANAPHYLACTIC:
Seen in bronchial asthma, Hay fever, food
allergies, drug reactions, bee stings.
Mast cells and basophils make histamine.
Reaction occurs in minutes
HYPERSENSITIVITY REACTIONS:
Type II
CYTOTOXIC or autoimmune:
Eruthroplasosis fetalis
Goodpatures
IgG and IgM produced
Reaction takes hours to days .
HYPERSENSITIVITY REACTIONS:
Type III
IMMUNE COMPLEX
Seen in serum sickness, acute
glomerulonephritis, SLE, Arthus reaction. IgG/ antigen antibodycomplex produced.
Takes days
HYPERSENSITIVITY REACTIONS:
Type IV:
DELAYED:
Seen in TB testing, transplant rej ection, comtact dermatitis (poison ivy).
Antigen sensitive T cells. contact
Takes a few days
ARTHRITIS:
Rheumatoid:
Inflammatory condition usually begins in the hands.
SYmmetrical distribution.
Leads to deformity (ulnar deviation of the wrist) and ankylosis in the spine.
produces)***pannus jformation over the joints (an exudate on synovial cells.
Hayqarth’s and Bouchard’s nodes.
Hayqarth’s
MCP
Bouchard
PIP
ARTHRITIS:
Osteoarthtis
A degenerative change that occurs in everyone.
Usually unilateral in ,distribution in weight bearing
joints such as thip and knees.
Produces decreased joint spacee, subchondral sclerosis and osteophytes
ARTHRITIS:
Gouty arthritis
inability to digest purines
Produces synovial thickening and secondary inflammatory edema
(no pannus)
Excess uric acid in the blood leads to tophi
formation
ARTHRITIS:
Reiters Disease:
Associated with Chalamidya associated with
conjunctivitis, urethritis and rheumaoid arthritis
ARTHRITIS:
SLE
Malar Rash
A collagen disease (autoimmune) that can produce
arthritis
Produce skin changes
Libman Sack endocarditis
Formation of anutobies against DNA
TEST - ANA tests
ARTHRITIS:
Gonococoal
Usually affects the knee
ARTHRITIS:
Hemophilia
usually affects the knee
Pannus
Hypertrophy of the synovium
Clotting cascade
Prothrombin: made in the liver and the liver puts it in the blood
- Moves into the blood
- With addition of calcium
- Thrombin
- Fibrinogen
- Clots
Type I
Anaphylactic
Time: 15- 30 min Imidiete
Disorder: Bee Sting, Hay fever Bronchiol asma
Immune Response: IgE , Mast cells Basophils
Type II
Cytotoxic
TIme: Min to hours
Disorders: Goodpateurs , Myseia Gravis, Erythroblastosis fetalis
Blood transfusions , Graves
Immune System:
IGG
Target cells , Phagocytosis
Type III
Immune Complex Disease
Disorder: Arthus reaction,
Serum sickness (Systemic Necrosis)
RA
Lupus
IGG
Type Iv
Cell mediated Delayed hypersensitivity
Disorder: TB, Contact Dermatitis, regected transplant
Cell: T cell
Goodpasturas = l
lung and kidneys
II
Anitgen directly attack
Use IgG
III
Antigen and antibody IgG