Path

Question 1

Ppl with Hashimoto’s are at risk for what?

Answer 1

B cell lymphoma

Question 2

A/w renal cell carcinoma in a child?

Answer 2

VHL

Question 3

Histo: Orphan annie eyes

Answer 3

A/w papillary carcinoma of the thyroid

Question 4

Histo: psammoma bodies

Answer 4

A/w papillary carcinoma of the thyroid

Question 5

Histo: nuclear grooves

Answer 5

A/w papillary carcinoma of the thyroid

Question 6

Hx: irradiation as a child

Answer 6

A/w papillary carcinoma of the thyroid

Question 7

RET mutations

Answer 7

A/w medullary OR papillary carcinoma of the thyroid

Question 8

Thyroid Histo: amyloid deposition

Answer 8

A/w medullary carcinoma of the thyroid

Question 9

Thyroid Histo: (+) stain for calcitonin

Answer 9

A/w medullary carcinoma of the thyroid

Question 10

MEN 2A gene

Answer 10

A/w medullary carcinoma of the thyroid

Question 11

MEN 2B gene

Answer 11

A/w medullary carcinoma of the thyroid

Question 12

Hx: “stones, bones, groans, & psychiatric undertones”

Answer 12

A/w primary hyperparathyroidism

Question 13

Hx: elderly with excessive thirst/polyuria

Answer 13

A/w Acquired DI (may be nephrogenic or central)

Question 14

Thyroid turned completely fibrosed?

Answer 14

A/w Riedel’s thyroiditis, common in middle-aged F

Question 15

Histo: granulomas and giant cells in thyroid?

Answer 15

A/w De Quervain’s thyroiditis, but may also be TB (if necrotizing) or sarcoidosis

Question 16

Gross: diffusely slightly enlarged, tender thyroid, a/w viral infection?

Answer 16

A/w De Quervain’s thyroiditis

Question 17

Gross: bronze skin

Answer 17

A/w Addison’s disease (adrenal insufficiency, usually autoimmune)

Question 18

Lab: morning serum cortisol below 3 mcg/dL

Answer 18

A/w Addison’s disease (adrenal insufficiency, usually autoimmune)

Question 19

Common cause of Addison’s outside the US?

Answer 19

TB

Question 20

Hx: Carpal tunnel

Answer 20

A/w Myxedema hypothyroidism

- predisposes to carpal tunnel bc of fluid excess compressing the nerve

Question 21

Thyroid Histo: germinal centers

Answer 21

A/w Hashimoto’s thyroiditis (hypothyroidism)

Question 22

Thyroid histo: lots of lymphocytes and big pinkish cells

Answer 22

A/w Hashimoto’s thyroiditis

- big pink cells are Hurtle cells

Question 23

Vitiligo

Answer 23

A/w Addison’s (adrenal insufficiency)

• bc of autoimmune destruction of melanocytes
• looks like hypopigmented patches of skin

Question 24

Thyroid histo/biopsy: diffusely eosinophillic change (looks magenta or darker)

Answer 24

A/w Hurthle cell metaplasia (adenoma or carcinoma)

Question 25

VHL?

Answer 25

Pheochromocytoma