Path 14: Pathology of Autoimmune Disorders Flashcards
1
Q
What are Primary (Congenital) Immune Deficiency Diseases?
A
Caused by mutations in genes involved in lymphocyte maturation or function, or in innate immunity
2
Q
What is X-linked agammaglobulinemia (XLA), or Bruton disease?
A
failure of B cell maturation, absence of B cells and antibodies; caused by mutations in BTK, which encodes a tyrosine kinase required for maturation signals from the pre-B cell and B cell receptors
3
Q
What is the most readily detected viral antigen for HIV screening?
A
P24
4
Q
Why is seroconversion rate of HIV so low?
A
It is extremely unstable outside the body
