Path 1 - Quiz #4 Flashcards
Blood coagulation
The principle mechanism of hemostasis
Blood clot
A mesh of protein filaments that traps blood’s formed elements to form a red, gelatinous mass
Fibrin threads
Threads that hold the Baltzell together and they seal the wound to prevent losing of blood
What activates clotting factors in the blood?
Injury; through extrinsic and intrinsic pathways.
Where are clotting factors produced?
Liver
What is required to produce clotting factors?
Vitamin K (via gut flora or external sources)
Clotting Factor I
Fibrinogen
Clotting Factor II
Prothrombin
Clotting Factor V
Preaccelerin
Clotting Factor VII
Proconvertin
Clotting Factor VIII
Antihemophilic factor
Clotting Factor IX
Christmas factor
Clotting Factor X
Stuart-Prower factor
Clotting Factor XI
Plasma thromboplastin antecedent
Clotting Factor XII
Hageman factor
Clotting Factor XIII
Fibrin-stabilizing factor
Extrinsic pathway takes place via…
Damage to cells within and outside the blood vessels
What is the extrinsic pathway portion of the coagulation cascade?
Tissue factor -> Proconvertin (CF7) -> Stuart-Prower Factor (CF10)
Intrinsic pathway takes place via…
Exposure of collagen fibers of us endothelial cells of blood vessels to blood flow. Thus, activating clotting factors.
Hemostasis
the process of stopping blood loss
What is the intrinsic pathway portion of the coagulation cascade?
Collagen fibers exposed -> Hageman factor (CF12) -> Plasma Thromboplastin Antecedent (CF11) -> Christmas factor (CF9) -> Stuart-Prower Factor (CF10)
