Past paper

Question 1

Mechanism of ciprofloxacin?

Answer 1

Inhibitors DNA gyrase

Question 2

Mechanism of sulphonamide and trimethoprim?

Answer 2

Inhibitors folate synthesis

Question 3

Acute side effect of meoclopramide?

Answer 3

Acute dystonia

Question 4

What cancers does tamoxifen increase risk of?

Answer 4

Endometrial and Uterine sarcoma

Question 5

Warm peripheries + hypotension

Answer 5

Low systemic resistance
Noradrenaline is vasopressor of choice

Question 6

Incubation of measles?

Answer 6

10 days

Question 7

Neurocytocosis?

Answer 7

FLuid filled spheres throughout both hemispehres

Caused by long term infection from pork tapeworm

Question 8

Treatment of neurocytocosis?

Answer 8

Albendazole + prazquintl + anti-epileptic meds

Question 9

What is the staging of hogdkin’s lymphoma?

Answer 9

PET-CT

Question 10

Staging of hogdkin’s lymphoma?

Answer 10

Stage 1:
- lymphoma in a single lymph node or one group of lymph nodes, or an organ of the lymphatic system (such as the thymus)
lymphoma in an extranodal site (1E)

Stage 2:
This means one of the following:

your lymphoma is in two or more groups of lymph nodes
your lymphoma is in an extranodal site and one or more groups of lymph nodes (2E)
In both cases, the 2 sites of lymphoma are on the same side of the diaphragm.

Stage 3: Disease both side of diaphragm

Stage 4: either side of diaphramg + at least one extranodal disease

Question 11

Thrombolysis candidate + Hypertensive

Answer 11

Treat hypertension until systolic 185 or less
Use Labetalol

Question 12

What recreational substance causes methaehaemoglobin?

Answer 12

Poppers

Question 13

Treatment for listeria meningitis?

Answer 13

Amoxicillin + Gentamicin

Question 14

Anti-anginal that causes ulceration?

Answer 14

Nicorrandil

Question 15

AF alone but no heart issues?

Answer 15

Atenolol - if only AF

Bisoprolol if heat problems

Question 16

Monitoring in sarcoidosis?

Answer 16

Treat when lung function affects
Or
Calcium levels elevated

Question 17

Juvenile myoclonoic epilepsy treatment?

Answer 17

Levetiracetam - female
Valporate male

Question 18

GCS that classifies as severe malaria according to WHO?

Answer 18

GCS 11

Question 19

Haemophilia B bleeding - management/

Answer 19

Factor 9

Question 20

Circular lesions 1-2 mm on feet

Answer 20

Granuloma annular

Question 21

Discharge after primary pneumothroax aspiration

Answer 21

They are well - discharge

Question 22

Forceful apexbeat + Syncope + deep T waves ( welleans) + late systolic murmur?

Answer 22

HOCM

Question 23

Antibiotics that may precipitate torsades?

Answer 23

Macrolides
Lengthen QT

Question 24

Renal impairment + UTI?

Answer 24

1. Trimethorpim
   Can use if eGFR > 15
2. Pivmecillinam

Question 25

Massive splenomegally?

Answer 25

Think myelofibrosis

Question 26

Cells to confirm / monotir myelfibrosis?

Answer 26

CD34+ve

Question 27

What is needed for diagnosis of PCOS?

Answer 27

Biochemical: can be clinical i.e. acne or test transvaginal ultrasound

Question 28

What liver thing is associated with ulcerative colitis?

Answer 28

Primary sclerosing cholangitis

Question 29

Peural tap: Lymphocytes + Ph < 7.2 + low glucose

Answer 29

Tuberculosis

Question 30

Pneumonia + erythema multiforme?

Answer 30

Mycoplasma

Question 31

Pneumonia + outbreaks

Answer 31

Mycoplasma

Question 32

Cancers that sclerotic + lytic lesions

Answer 32

Prostate Breast cancer Cervical cancer Testicular cancer Squamous cell carcinoma

Question 33

What is lincalotide?

Answer 33

guanylyl cyclase c receptor agonist Used in IBS with difficult constipation

Question 34

Treatment is wegners?

Answer 34

Cyclophosphamide or Rituximab + methylprednisolone

Question 35

How to differenate between anti-GBM disease and Wegner?s

Answer 35

Wegners --> elevated ESR

Question 36

When can ivabradine be used in heart failure

Answer 36

HR > 75 Ejection fraction < 35% patients already taking ramipril

Question 37

How best to manage prolactinoma?

Answer 37

Medical treatment Do surgery if medical fails

Question 38

How best to manage acromegally ?

Answer 38

Surgery is priority

Question 39

Multi-system atrophy?

Answer 39

Autonomic Parkinsonism Dementia

Question 40

EEG wave complexes + rapid progressive dementia + hyerreflexia + Mycoplconus

Answer 40

Sporadic CJD

Question 41

Starting adrenal replacement therapy?

Answer 41

Start 30 mg per day 2/3 in mane 1/3 at night

Question 42

What is the other option to calcium gluconate?

Answer 42

Calcium chloride

Question 43

Side effect of pyrazinamide?

Answer 43

Hepatitis

Question 44

Alpha blocker of choice in phaeochromocytoma?

Answer 44

Phenoxybenzamine

Question 45

What cancers are associated with coeliac disease?

Answer 45

small bowel t cell lymphoma Hodgkin's lymphoma

Question 46

Aortic dissection of ascending aorta /

Answer 46

Stanford type A

Question 47

Aortic dissection of descending aorta?

Answer 47

Stanford type B

Question 48

Gestational diabertes managenemtn booking glucose < 7?

Answer 48

Diet If diet fails --> metformin If metformin fails --> Insulin + metformin Aim to keep fasting glucose < 7

Question 49

Prednisolone dose in PMR?

Answer 49

15 mg prednisolone

Question 50

Management of methotrexate overdose ?

Answer 50

Folinic acid

Question 51

What rash is seen in primary billiary cholangitis?

Answer 51

Lichen planus

Question 52

Secondary syphilus has a papular rash

Answer 52

Secondary syphilus has a papular rash

Question 53

Choice of antibiotics for legionella?

Answer 53

Levofloxacin Clarithromycin / Erythromycin

Question 54

What is lentigo maligna/

Answer 54

Can transform to malignant melanoma

Question 55

Mutliple ulcers, erosions and intraluminal blood clots?

Answer 55

Inschaemic colitis