Passmed Qs

Question 1

SLE patients usually produce antibodies against …?

Answer 1

Doubke stranded DNA , ribonucleoprotein and histones

Question 2

Characteristic finding of lupus nephritis

Answer 2

Proliferator wire loop glomerular histology in the presence of proteinuria and systemic symptoms of sle

Question 3

Hydralazine can cause

Answer 3

Drug induced lupus

Question 4

Difference between lupus and SLE

Answer 4

both present with : arthralgia, fatigue , malar rash

But SLE would be positive for anti dsDNA antibodies rather than anti - histone antibodies

Question 5

Idiopathic membranous glomerulonephritis is related to what antibodies

Answer 5

Anti phospholipase A2 antibodies

Question 6

Over 99% of patients with SLE are positive for what antibody

Answer 6

ANA- antinuclear antibodies

Question 7

Where is cANCA commonly found

Answer 7

Granulomatosis with polyangitis

Question 8

Where is Panca usually found

Answer 8

Eosiniphillic granulomatosis with polyangitis and microscopic polyangitis

Question 9

What is the first radiological finding of AS

Answer 9

Sacroilitis

Question 10

Which organism is most likely to cause osteomyelitis in kids with sickle cell

Answer 10

Salmonella

Question 11

Ehlers danos is most commonly associated with a mutation in what type of collagen

Answer 11

Collagen type 3

Question 12

Two common heart issues associated with patients who have ehlers danos

Answer 12

Mitral valve prolapse
Aortic regurgitation

Question 13

narrow joint space, subchondral sclerosis , osteophytes indicates ?

Answer 13

osteoarthirtis

Question 14

phalens test

Answer 14

flex wrist for 60 seconds = carpal tunnel syndrome

Question 15

cauda equi na syndrome presents with

Answer 15

lassically presents with lower back pain, sciatica , reduced perianal sensation , late signs include urinary incontinence

Question 16

hypocalcaemia can cause

Answer 16

face twitching

Question 17

medication that can cause hypocalcaemia

Answer 17

desunumab

Question 18

Low serum calcium, low serum phosphate, raised ALP and raised PTH indicates

Answer 18

osteomalacai

Question 19

pseuudogout?

Answer 19

deposition of calcium pyrophosphate dihydrate crystals

Question 20

what is olecranon bursitis

Answer 20

describes inflammation of the olecranon bursa, the fluid-filled sac overlying the olecranon process at the proximal end of the ulna.

This bursa exists to reduce friction between the posterior aspect of the elbow joint and the overlying soft tissues

Question 21

plantar warts are caused by ?

Answer 21

HPV

Question 22

Boxer fracture commonly causes?

Answer 22

displacement of 5th metacarpal

Question 23

most common mechanism causing a scaphoid fracture

Answer 23

Falling onto an outstretched hand (FOOSH)

Question 24

reduction in red cells, platelets and white cells is known as ?

Answer 24

pancytopaenia

Question 25

chlorphenamine is what type of drug ?

Answer 25

H1 receptor agonist

Question 26

osteogenesis imperfecta occurs due to ?

Answer 26

abnormal type 1 collagen

Question 27

how do bisphosphonates treat osteoporosis

Answer 27

inhibit osteoclasts Osteoclasts that resorb the bone take up the bisphosphonate and are unable to adhere to the bony surface to continue resorption.

Question 28

What is the most common anatomical location for bursitis to occur?

Answer 28

olecranon

Question 29

two common causes of osteomyelitis with patients who have sickle cell

Answer 29

salmonella- more common s aureus

Question 30

histology for gout would show?

Answer 30

needle- shaped crystals with negative birefringence

Question 31

Why does felty syndrome present with

Answer 31

Triad of rheumatoid arthritis , neutropenia, splenomegaly

Question 32

list red flags for back pain

Answer 32

- peri anal anasthesia - dm weight loss - cancer - high impact trauma - history of cancer - urinary incontinence

Question 33

felty syndrome?

Answer 33

RA + splenomegaly , neutropenia

Question 34

Caplans Syndrome

Answer 34

RA+ intrapulmonary nodules

Question 35

common SE of hydroxychloroquine

Answer 35

Nightmares and loss of visual acuity

Question 36

what spine joint does RA affect

Answer 36

atlanto axial joint c1-c2

Question 37

most common organism to cause reactive arthritis

Answer 37

chlamydia trachomatis

Question 38

where would gout most likely present

Answer 38

big toe

Question 39

what would gout show on aspiration

Answer 39

negative birefringement with needle shaped crystals

Question 40

what would pseudogout show on aspiration

Answer 40

positive birefringement with rhomboid crystals

Question 41

treatment for gout

Answer 41

1st line NSAID if no ckd or gi issues IF CI then colchine

Question 42

se of colchine

Answer 42

diarrhoea nv

Question 43

what meds can exacerbate gout

Answer 43

thiazide like diuretics

Question 44

risk factors for pseudogout

Answer 44

Advanced age Injury or previous joint surgery Hyperparathyroidism Haemochromatosis Hypomagnesaemia Hypophosphataemia

Question 45

antibodies in sjogrens

Answer 45

Anti- ro Anti - la

Question 46

antibodies in antiphospholipid

Answer 46

ANTI Phospholipid lupus anticoagulant anticardiolipin anti beta 2 glycoprotein 1 antibodies

Question 47

complication of antiphispholipid

Answer 47

recurrent miscarriage

Question 48

ANTI JO 1 is most associated with

Answer 48

dermatomyositis

Question 49

A young patient with a history of active hepatitis B presents with systemic upset, nodular and ulcerating skin lesions and mononeuritis multiplex..,

Answer 49

polyarteris nodosa

Question 50

resp, renal and systemic features with positive PANCA is suggestive of ?

Answer 50

microscopic polyangitis

Question 51

canca +ve would indicate

Answer 51

granulomatosis with polyangitis

Question 52

what marker is used to monitor SLE

Answer 52

esr