Part A - MCQ1

Question 1

1. It is true about hematopoietic stem cells:
   a. They are totipotent cells
   b. Cytokines regulate stem cell division
   c. They are characterized by symmetric division
   d. Very few hematopoietic stem cells are present in blood
   e. They are present in the yellow bone marrow

Answer 1

b. Cytokines regulate stem cell division
d. Very few hematopoietic stem cells are present in blood

Question 2

2. Clotting factors which require post-translational modifications
   a. Factor XI
   b. Prothrombin
   c. Factor XIII
   d. Factor VIII
   e. Factor X

Answer 2

b. Prothrombin
e. Factor X

Question 3

3. It is true about thrombin:

a. Thrombin activates thrombocytes
b. Thrombin activates Factor XII
c. It is released from thrombocytes
d. After binding to thrombomodulin, thrombin activates Protein C
e. Very high thrombin concentrations promote fibrinolysis

Answer 3

a. Thrombin activates thrombocytes
d. After binding to thrombomodulin, thrombin activates Protein C

Question 4

4. It is true about thrombocytes

a. GP IIb-IIIa complex provides the binding of platelets to subendothelial collagen fibers
b. Thrombocytes are produced from macrophages
c. TXA2 released from activated platelets activates inactivated platelets
d. Thrombin bonds to its receptor on thrombocytes and induces elevation in Ca2+ concentration
e. alpha-granules contain adrenaline and serotonin

Answer 4

c. TXA2 released from activated platelets activates inactivated platelets
d. Thrombin bonds to its receptor on thrombocytes and induces elevation in Ca2+ concentration

Question 5

5. It is true about hemostasis

a. Plasmin inhibits thrombin
b. XIIIa is responsible for the cross linking between fibrin chains
c. Protein C inhibits Factor Va and VIIIa
d. Platelet plug provides permanent hemostasis
e. Clotting factors are produced in the bone marrow

Answer 5

b. XIIIa is responsible for the cross linking between fibrin chains
c. Protein C inhibits Factor Va and VIIIa

Question 6

6. Platelets are characterized by:
   a. alpha-granules containing Ca2+
   b. divided nucleus
   c. Dense granules containing ADP, adrenaline & serotonine
   d. Actin, myosin
   e. Specific adhesion glycoproteins and receptors

Answer 6

c. Dense granules containing ADP, adrenaline & serotonine
d. Actin, myosin
e. Specific adhesion glycoproteins and receptors

Question 7

7. It is true about blood coagulation
   a. Extrinsic pathway alone is able to produce enough thrombin to activate the TAFI
   b. XIIa initiates blood coagulation in vitro
   c. Vitamin K participates in the post-translational modifications of protein C
   d. Plasminogen-activator inhibitors are released from endothelial cells
   e. Factor XIII is a serine-protease

Answer 7

b. XIIa initiates blood coagulation in vitro
c. Vitamin K participates in the post-translational modifications of protein C
d. Plasminogen-activator inhibitors are released from endothelial cells

Question 8

8. It is true about blood coagulation
   a. Intrinsic pathway can be initiated by thrombin
   b. Protein C is an anticoagulant which cleaves thrombin
   c. Factor VIII is activated by fibrin
   d. Plasminogen-activator inhibitors are released from activated thrombocytes
   e. Collagen fibers are able to bind GP Ia-IIIa and GP VI

Answer 8

a. Intrinsic pathway can be initiated by thrombin
e. Collagen fibers are able to bind GP Ia-IIIa and GP VI

Question 9

9. It is false about the formation of platelet plug
   a. GP Ia-IIa binds platelets directly to subendothelial collagen fibers
   b. Activated thrombocytes release ADP
   c. Increased Ca2+ in thrombocytes activates the cytoskeleton
   d. Intact endothelial surface inhibits platelet activation
   e. Adrenaline and serotonin inhibit platelet activation

Answer 9

e. Adrenaline and serotonin inhibit platelet activation

Question 10

10. Anticoagulants
    a. Thrombin activable fibrinolysis inhibitor
    b. Tissue factor pathway inhibitor
    c. Thrombomodulin
    d. plasmin inhibitor
    e. Antithrombin

Answer 10

b. Tissue factor pathway inhibitor
c. Thrombomodulin
e. Antithrombin

Question 11

11. Actions of thrombin
    a. Thrombocyte activation
    b. Conversion of XII to XIIa
    c. Conversion of XI to XIa
    d. Conversion of V to Va
    e. Activation of plasminogen activators

Answer 11

a. Thrombocyte activation
c. Conversion of XI to XIa
d. Conversion of V to Va

Question 12

12. It is true about the regulation of hematopoiesis

a. Thrombopoietin is produced mainly in the kidney
b. Thrombopoietin affects the megakaryocytic-erythrocyte progenitor
c. IL-7 deficiency leads to T-lymphocytopenia
d. G-CSF stimulates the production of osteoclasts
e. M-CSF affects stem cell divisopm

Answer 12

c. IL-7 deficiency leads to T-lymphocytopenia

Question 13

13. Which formed element is not derived from myeloid progenitor cell

a. Natural killer cell
b. RBC
c. monocyte
d. platelet
e. eosinophil granulocyte

Answer 13

a. Natural killer cell

Question 14

14. Which factor affects stem cells?
    a. G-CSF
    b. SCF
    c. M-CSF
    d. IL-7
    e. Thrombopoietin

Answer 14

b. SCF

Question 15

15. It is true:
    a. ß thalassemia is characterized by spectrum or nnkyrin defect
    b. Spherocytosis provides benefit against malaria
    c. Incompatible blood group transfusion results in kidney failure
    d. O-gene codes H-antigen
    e. ABO antibodies are IgMs

Answer 15

c. Incompatible blood group transfusion results in kidney failure
e. ABO antibodies are IgMs

Question 16

16. It is true:
    a. ß thalassemia is due to disorders of Vitamin B12 absorption
    b. ABO antigens exist only on RBCs
    c. Anaemia perniciosa is characterized by production of antibodies against intrinsic factor
    d. Iron deficiency anaemias are microcytic hypo chromic anaemias
    e. IgMs are responsible to erythroblastosis foetalis

Answer 16

c. Anaemia perniciosa is characterized by production of antibodies against intrinsic factor
d. Iron deficiency anaemias are microcytic hypo chromic anaemias

Question 17

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