part 4 (b-oxidation) Flashcards
A series of five enzyme-catalyzed reactions
that cleaves carbon atoms two at a time from the carboxyl end of a fatty acid.
B-Oxidation
What is the first reaction of B-Oxidation
The fatty acid is activated by conversion to an Acyl CoA
What is the second reaction of B-oxidaion
Oxidation by FAD of the a,b carbon carbon single bond to a carbon carbon double bond
What is the enzyme responsible for the second reaction of B-Oxidation
Acyl-CoA dehydrogenase
What is the third reaction of B-oxidation
Hydration of the Carbon carbon double bond to a 2° alcohol
What enzyme is responsible for the third reaction
Enoyl-CoA hydratase
What is the fourth reaction of B-Oxidation
Oxidation of the 2° alcohol to a ketone
What enzme is responsible for the fourth reaction
B- Hydroxyacyl-CoA Dehydrogenase
What is the fifth reaction of B-oxidation
Cleavage of the carbon chain by a molecule of CoA-SH
What enzyme is responsible for the fifth reaction of B-Oxidation
Thiolase
This cycle of reactions (B-Oxidation) is then repeated on the shortened fatty acyl chain and continues until the entire fatty acid chain is degraded to ______
Acetyl CoA