Part 3 - Applications of nanoparticles Flashcards
Why are gold nanoparticles desireable for applications?
- Good control of size (0.8 - 200nm)
- Can be functionalized with large number things
- Low cytotoxicity
- Enormous light extinction characteristic in visible regime.
What is pharmacology?
The study of the effect of pharmaceuticals
What is pharmacodynamics?
What does the drug do to the body?
What is pharmacokinetics?
What does the body do to the drug?
What is pharmacogenetics?
What is the individual/genetic response?
What are the golden rules of drug delivery?
- Monodisperse NP population (5-200 nm)
- Biocomptaible, low toxicity
- Long circulation times
- Target specific
- Delivery of cargo
Break down the importance of size in drug delivery.
What are the four main steps with the drug delivery process?
1) Administration - how the drug is administered (oral, nasal, pulmonary, transdermal, parenteral
2) Distribution - how is the drug delivered where it’s supposed to go? (passive targeting, active targeting)
3) Metabolism - how is the drug delivery device metabolized and the drug uptaken?
4) Elimination - how does the body get rid of the delivery vector?
What is the EPR effect?
Enhanced permability and retention.
The effect that small particles tend to accumulate with tumors.
What is the passive targeting based on?
The EPR-effect. Small particles tend to accumulate in tumors.
What is active targeting?
Functionalizing delivery vectors with receptor-selective molecules that mediates endocytosis.
What is the basic principle of photothermal delivery?
Delivering the drugs to a desired place using passive or active targeting, then releasing drug by heating the material with LSPR.
What are some challenges with LSPR heating of gold nanoparitcles in drug delivery systems?
Most LSPR peaks are in the visible region -> hard to penetrate skin. Just make nanorods instead and shift peak into IR ;D
