Part 2

Question 1

Triad of ophthalmoplegia, ataxia and areflexia

Answer 1

Miller-Fisher syndrome. a post-viral variant of Guillain Barre syndrome.Commonly after GI infections positive anti GQ1b antibodies.

Question 2

Aquaporin 4 autoantibodies

Answer 2

Neuromyelitis Optica

Question 3

LTOT indication

Answer 3

pO2 of < 7.3 kPa or to those with a pO2 of 7.3 - 8 kPa and one of the following:
secondary polycythaemia
nocturnal hypoxaemia
peripheral oedema
pulmonary hypertension

Question 4

King’s College criteria for acute transplantation following paracetamol overdose

Answer 4

Blood pH <7.3
INR>6.5
Creatinine >300µL
Grade 3 or 4 hepatic encephalopathy

Question 5

Drug to prevent kidney stones: calcium

Answer 5

Thiazides

Question 6

Drug to prevent kidney stones: oxalate

Answer 6

cholestyramine or pyridoxine

Question 7

Drug to prevent kidney stones: uric arid

Answer 7

allopurinol

Or urinary alkalisation with oral sodium bicarbonate

Question 8

Drug to prevent kidney stones: struvite

Answer 8

Acetohydroxamic acid - strong urease inhibitor