Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Internal Medicine > Part 15 - Allergology, Immunology, Rheumatology > Flashcards

Part 15 - Allergology, Immunology, Rheumatology Flashcards

1
Q

In SLE, what complement deficiencies are involved?

A

C1q,r,s
C2
C4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

People with ______ karyotype have a significantly increased risk for SLE.

A

XXY (Klinefelter’s)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

In SLE, at what skin layer (on skin biopsies) is deposition of immunoglobulin found?

A

Dermal-epidermal junction (DEJ)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

At what class of disease is treatment for lupus nephritis NOT recommended?

A

Class I or II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the name of the criteria for classification of SLE?

A

Systemic Lupus International Collaborating Clinic (SLICC)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the most common pattern of vasculitis in SLE, that may also indicate active disease?

A

Leukocytoclastic vasculitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

In SLE, ANA is positive in how many percent of patients during the course of disease?

A

> 98%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the best screening test for SLE?

A

ANA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What autoantibodies are specific for SLE?

A

Anti-dsDNA

Anti-Sm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What autoantibody is SLE-specific and may correlate with disease activity?

A

Anti-dsDNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which autoantibody is more frequently seen in drug-induced lupus than in SLE?

A

Antihistone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which autoantibody, when produces a positive test in serum correlates with depression or psychosis due to CNS lupus?

A

Antiribosomal P

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

In SLE, what is the gene defect found on the X chromosome?

A

Mutation in TREX1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the types/classes of lupus nephritis?

A 
Class I: minimal mesangial
Class II: mesangial proliferative
Class III: focal
Class IV: diffuse
Class V: membranous
Class VI: advanced sclerotic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is “Rhupus”?

A

Rheumatoid-like arthritis with erosions and fulfill criteria for both RA and SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

In SLE, what diagnosis will you consider if arthralgia is persistent in a single joint?

A

Ischemic necrosis of bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the most common chronic dermatitis in lupus?

A

Discoid lupus erythematosus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the treatment for discoid lupus erythematosus?

A

Topical or locally injected glucocorticoids and systemic antimalarials

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is the most serious manifestation of SLE?

A

Nephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the most common manifestation of diffuse CNS lupus?

A

Cognitive dysfunction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

In SLE, at what dose of Prednisone does glucocorticoid-induced psychosis occur?

A

> or = to 40 mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Endocarditis of SLE is called?

A

Libman-Sacks endocarditis

23
Q

What is the most common pulmonary manifestation of SLE?

A

Pleuritis with or without pleural effusion

24
Q

Life threatening pulmonary manifestations of SLE

A

Interstitial fibrosis
Shrinking lung syndrome
Intraalveolar hemorrhage

25
What is the most frequent cardiac manifestation of SLE?
Pericarditis
26
Endocardial involvement in SLE may lead to insufficiencies commonly on what valves?
Mitral or aortic
27
What is the most frequent hematologic manifestation of SLE?
Anemia | usually normochromic normocytic
28
What are serious ocular manifestations of SLE that may cause blindness?
Retinal vasculitis | Optic neuritis
29
Three antiphospholipid antibodies
Anticardiolipin anti-B2 glycoprotein Lupus anticoagulant
30
What titer level of IgG anticardiolipin is considered high?
>40 IU
31
What is the criteria for diagnosing APS?
Presence of 1 or more clotting episodes and/or repeated fetal losses PLUS at least 2 positive tests for antiphospholipid antibodies at least 12 weeks apart
32
What autoantibody indicates increased risk for neonatal lupus, sicca syndrome, and subacute cutaneous lupus?
Anti-Ro (SS-A)
33
What treatment has been shown to prevent SLE flares in patients with rising anti-DNA plus falling complement?
30 mg Prednisone daily for 2 weeks
34
Antimalarials used for treatment of SLE
Hydroxychloroquine Chloroquine Quinacrine
35
Mainstay of treatment for any inflammatory life-threatening manifestations of SLE
Systemic glucocorticoids (0.5-1 mg/kg per day PO OR 500-1000 mg of methylprednisolone succinate IV daily for 3 days followed by 0.5-1 mg/kg of daily prednisone or equivalent
36
Cytotoxic/immunosuppressive agents added to glucocorticoids for treatment of severe SLE
Cyclophosphamide or mycophenolate mofetil
37
Alkylating agent used to treat serious SLE
Cyclophosphamide
38
Lymphocyte specific inhibitor of inosine monophosphatase / purine synthesis used to treat serious SLE
Mycophenolate mofetil
39
Common manifestation of mycophenolate mofetil toxicity
Diarrhea
40
Common manifestations of cyclophosphamide toxicity
Amenorrhea Leukopenia Nausea
41
Common effect of high dose cyclophosphamide (not low dose)
Ovarian failure
42
Given to reduce incidence of ovarian failure due to high-dose cyclophosphamide therapy for SLE
Gonadotropin-releasing hormone agonist (ex. Leuprolide 3.75 mg IM) prior to each cyclophosphamide dose
43
Can be used if necessary to control active SLE in pregnant patients (if conventional therapy do not work)
Azathioprine
44
A folinic acid antagonist that may be used for treatment of arthritis and dermatitis due to SLE (but not in nephritis or life-threatening disease)
Methotrexate
45
Anti-BLys agent used for treatment of seropositive patients with SLE who have failed standard treatments
Belimumab
46
Widely used scoring to measure SLE disease activity
Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)
47
What score in SLEDAI reflects clinically active disease in SLE?
>3
48
Induction therapy of choice for crescentic lupus nepritis
High-dose cyclophosphamide
49
Placental enzyme that deactivates glucocorticoids
11-B-dehydrogenase 2
50
Pregnancy category of methotrexate
Category X
51
Pregnancy category of azathioprine, hydroxychloroquine, mycophenolate mofetil, and cyclophosphamide
Category D
52
Pregnancy category of cyclosporine, tacrolimus, rituximab
Category C
53
Pregnancy category of glucocorticoids
Category A
54
Active SLE in pregnant women should be controlled with?
Hydroxychloroquine > prednisone/prednisolone (lowest possible dose) > azathioprine

Internal Medicine (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions