Part 1 - Exercise Sciences Flashcards
What are tropomyosin and troponin?
Regulatory proteins that regulate the interaction of myosin and actin.
Tropomyosin sits on the binding sites of myosin and each tropomyosin has a troponin head that responds to calclium. The presence of calcium causes tropomyosin to lift and allow the binding of actin to myosin and subsequent contraction.
What is a sarcomere?
The basic contractile unit of muscle.
One z-line to the next z-line
True or false? Each muscle fiber has a single neuromuscular junction
True
located at the approximate centre of the cell
When stimulated, muscle fibers always attempt to ____. That is, the cross-bridges always attempt to pull ____ towards the centre of the _____.
When stimulated, muscle fibers always attempt to shorten. That is, the cross-bridges always attempt to pull actin towards the centre of the sarcomere.
What is a concentric muscle action?
Shortening of a muscle (e.g. bicep with curls)
What is a eccentric muscle action?
Lengthening of a muscle when force applied to it overcomes contractile force (e.g. the weight of a dumbbell lengthening a bicep when it is at ‘rest’ and lowering the dumbbell back down after a concentric action)
What is the most likely cause for delayed onset muscle soreness?
Eccentric muscle actions causing connective/muscle tissue damage and inflammatory response.
Exercise may actually be the best analgesic relief for DOMs.
What is the concept of ‘specific tension?’
Specific tension: Maximal force production and fiber efficiency differing relative to their size (cross-sectional area)
How can differing levels of myosin ATPase effect contractile characteristics of muscle?
Myosin ATPase splits ATP and produces energy for contraction.
More ATPase will cause a muscle to have a high rate of shortening (shortening velocity)
What are slow-twitch fibers and fast-twitch fibers?
Slow-twitch: Type 1. Not much ATPase. Don’t fatigue easily but contract and relax slowly.
Fast-twitch: Type 2. Large and powerful, with moderate to high anaerobic metabolic capability. There are two types, fast oxidative glycolytic (FOG) which are moderate oxidative and anaerobic providing them with some fatigue resistance. The other is purely anaerobic and highly fatigable fast glycolytic.
The difference between these two types of fibers is continuous, not binary.
What is the difference between a muscle spindle and a golgi tendon organ?
Muscle spindle: in the middle of a skeletal muscle. Stretch receptor with sensory receptors around intrafusal fibers (surrounded by regular extrafusal fibers).
The golgi tendon organ is located a the junction of the muscle and tendon that attaches the muscle to bone. Deformed when muscle is activated, it protects the muscle from harm by detecting excessive force and reflexively relaxing the active muscle and stimulating the antagonistic muscle.
Define a motor unit
All the muscle fibers supplied by one motor neuron (the neuron is part of the unit).
What are two ways a muscle can increase maximum force of contraction (gradation of force)?
Motor unit recruitment (recruiting more motor units in the order type I (slow twitch), type IIa (fast oxidative glycolytic), and type IIx (fast glycolytic). When the larger fast twitch fibers are recruited there is a second big onset of blood lactate accumulation (OBLA).
Rate coding (Increasing firing rate of already activated motor units).
Resistance training allows people to recruit more muscle units AND have higher maximal motor unit discharge rates than untrained individuals.
What are the best forms of exercise for increasing bone mineral density?
- Weight-bearing exercises like walking and running.
- Resistance training.
Keep this in mind for osteoporosis clients (e.g. walking for bone mineral density in lower limbs).
How does exercise force the oxyhemoglobin dissociation curve to the right and therefore release oxygen at higher partial pressure so that it can be used by the working muscle rather than staying bound to hemoglobin?
- Raising body temperature
- Increasing acidity of blood (lowering pH)
The estimate of the rate-pressure product (RPP) or double product of the heart is obtained by ____?
RPP = Systolic blood pressure * heart rate
indirectly measures myocardial oxygen uptake
How do you obtain cardiac output?
What is the Frank-Starling principle?
The amount of blood pumped by the heart in 1 minute.
Cardiac output: stroke volume * Heart rate
Stroke volume: End-diastolic volume - end-systolic volume
AKA: CO = (EDV - ESV) * HR
The Frank-Starling principle states that the more the left ventricle is stretched, the more forceful the contraction and thus the greater volume of blood leaving the ventricle. This principle is thus based on the length-tension relationship. An increase in preload (EDV) is directly influenced by the heart volume and venous return of blood to the heart.
True or false? The same muscle(s) is used during breathing at rest and during exercise.
False
The diaphragm is used at rest, but the diaphragm, pectoralis major/minor, scalene, sternocleidomastoid, and intercostal muscles are involved to facilitate airflow in.
What is spirometry?
Using a spirometer to measure lung volumes.
What is the Fick equation for oxygen uptake (VO2)
VO2 = HR * (end diastolic volume - end systolic volume) * (artial oxygen content - venous oxygen content
Relay the heart’s conduction pathway
The conduction system of the heart. Left: Normal excitation originates in the sinoatrial (SA) node then propagates through both atria. The atrial depolarization spreads to the atrioventricular (AV) node, and passes through the bundle of His to the bundle branches/Purkinje fibers.
How does lactate clearance relate to conditioning in individuals?
What is the lactate threshold?
Individuals with more training tend to clear lactate faster than training novices. Lactate clearance is a good metric for recovery rates.
Lactate does not contribute to lower blood pH than other intermediates of glycolysis.
Lactate can be used in gluconeogenesis.
The lactate threshold is the exercise intensity or relative intensity at which blood lactate begins an abrubt increase above the baseline concentration, it represents an increase reliance on anaerobic mechanisms (50-60 in untrained, 70-80 in trained).
At what intensities of exercise are the following pathways used?
- Phosphagen
- Glycolytic
- Oxidative
- Phosphagen: high-intensity
- Glycolytic: moderate to high-intensity for short to medium duration
- Oxidative: low intensity of long duration
True or false? The higher the oxygen uptake the more fit a person is considered to be
True
Which of the following describes what a client would be doing to allow the oxidative system to contribute the greatest percentage toward total ATP production?
- Sitting quietly
- Walking
- Jogging
- Sprinting
Sitting quietly.
Novices use up oxygen quickly and switch over to anaerobic quickly. Trained individuals can use oxygen longer and more efficiently.