Part 1: Basics of Pharmacology in Rehabilitation Flashcards
Chemical Name
Long, awkward, not useful clinically
Generic Name
Short hand version of the chemical name
Trade Name
Marketing tool to achieve name recognition
Patent life of a drug
~20 years
Government agency that oversees drug testing/approval process
FDA (Food and Drug Administration)
Phases of Drug Testing
Preclinical Trials Clinical Trials: Phase I (Healthy volunteer) 1 year Phase II: Small pt sample 2 years Phase III: Large pt sample 3 years Phase 4: Post marketing surveillance
Pharmacokinetics
How the body handles the drugs
Pharmacodynamics
How the drugs affect the body
Factors of Pharmacokinetics
Administration; Absorption; Distribution; Storage; Elimination
Enteral
Using the GI tract for administration
Parenteral
Not using the GI tract for administration
Enteral route trade off
Simple, easy; less predictable absorption
Parenteral route trade off
More difficult, inconvenient; more predictable absorption
Odds of drug approval
5000 compounds—>5 clinical trials—->1 approved
Implications of drug testing/approval
Drug costs
Availability
Failure to identify side effects