Part 1 Flashcards

1
Q

% of patients who develop dependence syndrome on benzodiazepines after taking them for a year

A

40%

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2
Q

How much heroine does a typical user consume a day?

A

0.25-2g

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3
Q

Drug named ice

A

Strong and pure form of amphetamine

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4
Q

ACUTE side effect of lsd

A

Bad trips

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5
Q

Suboxone

A

Buprenorphine and nalaxone

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6
Q

Flunitrazepam

A

Date rape, tasteless, short acting potent benzodiazepine

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7
Q

Most commonly used opoid in the country

A

Heroine

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8
Q

Cold turkey

A

Opiate withdrawal

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9
Q

Opiate withdrawal

A

Begins 6-8 hours after last dose
Peaks in 2 days
Dysphoric mood, nausea or vomiting, muscle aches, lacrimation or rhinorrhoea, pupil dilation, goose flesh (piloerection), sweating, diarrhoea, yawning, insomnia
Withdrawal symptoms reach their peak after 32-72 hours

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10
Q

When’s it the best time for a pregnant woman to start opoid detoxification

A

2nd trimester

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11
Q

Common s/e of clonidine

A

Sedation

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12
Q

What is the risk of seizures assoc. with bupropion

A

1 in 1000

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13
Q

What type of hallucinations do you get in benzodiazepine withdrawal

A

Kinaesthetic

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14
Q

This is partly a hallucinogenic and stimulant. It is a substituted amphetamine

A

MDMA

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15
Q

Main s/e of varenicline

A

Nausea

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16
Q

How may caffeine elevate mood?

A

Increasing noradrenaline

17
Q

What drug causes the following intoxication:
Marked anxiety and depression
Ideas of reference, fear of losing mind, perceptual changes, depersonalisation, derealisation, synesthesia
Pupil dilation, sweating, palpitations, blurring of vision

A

Pcp

18
Q

How many people with alcohol withdrawal develop delirium tremens

A

5%

19
Q

What is triad of wernickes encephalopathy and how often is it seem

A

Ataxia, confusion, opthalmoplegia

10%

20
Q

% of men and women who drink above weekly limits of alcohol

A

Men - 27%

Women - 15%

21
Q

What is lifetime risk of suicide in dependent drinkers

A

10-15%

22
Q

Minimum duration required to make diagnosis of alcohol dependence

A

12 monthes

23
Q

How often is cerebellar degeneration reported in chronic alcoholics

A

40%

24
Q

What is dose of acamprosate in people over 60kg

And for those less than 60kg

A

666mg tds

666mg morning, 333mg mid-day, 333mg evening

25
Q

When do symptoms of delirium tremens peak after last drink?

A

72-96 days

26
Q

Chlormethiazole - why is this not used in alcohol detox

A

High risk of respiratory depression

27
Q

What does acamprosate act on

A

Synthetic taurine analogue
Acts on glutamate and gaba
Gi disturbance is most common s/e

28
Q

Common s/e disulfiriam

A

Halitosis

29
Q

Patients with wernickes encephalopathy show gliosis and small haemorrhages in:

A

Mammillary bodies

30
Q

Drug choice in alcohol detoxification in patients with chronic respiratory disease

A

Oxazepam

31
Q

Type 1 alcoholism

A

Milieu-limited ( caused by environmental factors ie living with alcoholics)
Seen in equally in men and women
No family history of alcoholism
Use generally starts above age of 25

32
Q

Safe limit of alcohol consumption in men and women

A

Men: 21 units
Women: 14 units

33
Q

Opoid detox with buprenorphine inpatient should last

A

7-14 days

34
Q

Amphetamine withdrawal

A

Dysphoric mood, suicide ideas, fatigue, vivid unpleasant dreams, increased appetite, hypersomnia, psychomotor retardation

35
Q

Current prevalence of heroin use in the uk ?

A

1%