Parkinsons

Question 1

Pt suffering from hallucinations. What order would you cease meds?

Answer 1

1. drugs least involved in PD (ie. oxybutynin)
2. anticholinergics
3. amantadine
4. MAOB inhibs
5. COMTs
6. Dopamine agonists
7. Levodopa

Question 2

Clinical features of PD

Answer 2

TRAP
involuntary Tremor
Rigidity
Akinesia or bradykinesia
Muscle weakness
loss of Posture

Question 3

What neurotransmitter in primarily involved?

Answer 3

Dopamine

***also a loss or NA Ach 5HT

Question 4

What happens in brain to cause symptoms? ***

Answer 4

• dopaminergic neurones from the SNc send dopamine along nigrostriatal pathways to the dorsal striatum for motor control*?
• degeneration of the nigrostriatal dopaminergic pathway
• degeneration of dopamine neurons of the SNc( substantia nigra pars compacta)
• impaired synth, storage, release of dopamine
• decreased striatal concentration of dopamine