Parkinson's Disease Flashcards

1
Q

Lewy Bodies are?

A

clumps of protein in the surviving dopaminergic neurons of the substantia nigra

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2
Q

what is global cerebral ischema?

A

people that have experienced an interruption of blood to their entire brains

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3
Q

what is retrograde transneuronal degeneration?

A

spreads from damaged neurons to the neurons that synapse on them

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4
Q

what is anterograde transneuronal degeneration?

A

spreads from damaged neuron to the neurons on which they synapse

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5
Q

What is retrograde degeneration?

A

the degeneration of the proximal segment

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6
Q

What is anterograde degeneration?

A

the degeneration of the distal segment

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7
Q

what is a distal segment?

A

the segment of a cut axon between the cut and the synaptic terminal

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8
Q

what is a proximal segment?

A

the segment of a cut axon between the cut and the cell body

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9
Q

What does early degeneration indicate?

A

that the cell will die

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10
Q

which cells are influential for degeneration?

A

glial cells

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11
Q

What was the MPTP?

A

a synthetic type of heroin which caused Parkinson’s disease

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12
Q

What are the important aspects of Parkinson’s and the brain?

A

the substantia nigra, lewy bodies and dopamime

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13
Q

Why is Parkinson’s hard to treat?

A

it is a progressive developmental disease

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14
Q

What is the major correlate of Parkinson’s disease?

A

a reduction of dopamine in the substantia nigra and striatum

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15
Q

Why does L-DOPA not give a solution to Parkinson’s disease?

A

because it becomes less and less therapeutically effective with use.

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