Parkinson's Disease Flashcards by Butch Cabatu | Brainscape

Q

Crosses blood brain barrier

A

Levodopa

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Q

Peripherally administered dopamine cannot cross BBB

A

Levodopa

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Q

Levodopa

A

Low intermediate metabolic precursor of dopamine
Most are decarboxylated in the periphery by aromatic L amino - acid decarbocylated and does not reach the brain neurons
A good way to prevent this is to give carbidopa together with levodopa

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Q

1st line for Parkinson’s

A

Carbidopa

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Q

A competitive inhibitor of carboxylase

Does not cross BBB

A

Carbidopa

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Q

DOC for Parkinson’s

A

Levodopa + Carbidopa

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