Parkinson's Disease

Question 1

Neurodegenerative Diseases
• Caused by death of neurons (necrosis or apoptosis)
1.
2.

Answer 1

1• Parkinson’s disease (PD)

2• Alzheimer’s disease (AD)

Question 2

___________ Disease
• 1817—first described as a shaking palsy
• Loss of ________ neurons in substantia nigra
• ______ ______ in dopamine neurons—protein aggregates

Answer 2

Parkinson’s

• dopamine
• Lewy bodies

Question 3

PD Pathology
• Sensitive to _______ ______
• Environmental toxins
• Drug induced—antipsychotics (___ ___________)
• Genetic risk - _____ onset, more aggressive
• Why so long for symptoms to develop? _________________________

Answer 3

• Oxidative damage

• (D2R antagonists)
• Earlier onset
• 80% of DA neurons have to die before see s/sx of Parkinson’s

Question 4

Hallmark Symptoms of PD
•	Disorder of \_\_\_\_\_\_\_\_\_\_
•	\_\_\_\_\_\_\_\_\_\_\_\_\_\_
•	Muscle \_\_\_\_\_\_\_\_
•	Resting \_\_\_\_\_\_\_\_
•	Postural instability

Answer 4

Hallmark Symptoms of PD
•	movement
•	Bradykinesia
•	rigidity
•	tremor

Question 5

Other symptoms of PD
•	\_\_\_\_\_\_\_\_\_\_\_
•	Weight \_\_\_\_
•	\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
•	Difficulty \_\_\_\_\_\_\_\_\_\_
•	Reduced frequency of \_\_\_\_\_\_\_
•	Decreased \_\_\_\_\_\_ expressions
•	Reduced arm swing on one side when walking
•	Quiet speech

Answer 5

• Micrographia
• loss
• Constipation
• swallowing
• blinking
• facial