Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IP3 > Parkinson's, ADHD, Bipolar > Flashcards

Parkinson's, ADHD, Bipolar Flashcards

1
Q

main SE of DA agonist

A

psychosis

compulsiveness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

do all sga treat mania?

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

DA agonists (6)

A

Bromocriptine

Cabergoline

Pramipexole

Ropinirole

Apomorphine

Rotiogotine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Antipsychotic drugs for BP (4)

A

Olanzapine Quetiapine Risperidone Aripiprazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

stalevo

A

levodopa carbidopa entacapone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

pramipexole MAO

A

d2 agonist D3 agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

lithium target for bp

A

0.8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

main protein in Lewy Bodies

A

alpha-synuclein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

COMT inhibitors (3)

A

entacapone

tolcapone

opicapone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what % of DA loss is needed before symptoms appear

A

60-80

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

BP 2 mintenance tx (3)

A

quetiapine lithium LMG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

week 2 BP based on response

A

full: continue tx

m-m: continue, inc. dose

s: inc. dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

apomorphine MOA

A

D2,3,4 agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

entacapone pearls (3)

A

must take with sinemet

dealyed onset diarrhea

dark urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

do all sga treat mdd

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

mixed BP episode

A

manic/hypomanic 3 depressive sx most days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

stage 1 BP tx

A

monotherapy

skip to stage 2 if

euphoric mania and psychosis

or

if acute mania and on chronic tx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Selefiline MOA

A

irreversible inhibitor of MOA-B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

lithium MOA

A

inhibit Ne and Da release inhibit inositol phosphates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

lithium monitor (2)

A

tsh: hypothyroidism renal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Non-motor symptoms of PD (6)

A

neuropsychiatric –dementia, psychosis autonomic –orthoHTN, anti-ach falls sleep disorders –RLDS gI –drooling, dysphagia misc –fatigue, diplopia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Thiazide and lithium

A

inc. li

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Maintenance phase bp tx

A

dose dec.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

loop and lithium

A

inc. li

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

SE of bromocriptine

A

pulmonary fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

tx for diphasic dyskinesias (5)

A

more frequent sinemet

add DA agonist

add amantadine

add comt inhibitor

liquid sinemet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Rotiogotine MOA

A

D1,2,3 agonist

5ht agonist

antagonist of alpha adrenergic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Define Akinesia

A

unable to move muscles voluntarily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Continuation phase BP

A

full resonse 4-6 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

type of peak dyskinesia (2)

A

chorieform dystonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

acute mania tx (euphoric only) (8) in Bp

A

lithium

seroquel

divaloproex

asenapine

aripiprazole

paliperidone

risperidone

cariprazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Sinemet MOA

A

inhibit dopa decarboxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Bupropion CI

A

bulemia nervosa seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

TCA ADHD indication

A

ADHD w/anxiety/depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

why slow taper LMG

A

prevent steven johnson’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Stage 1 of PD

A

unilateral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

>__?___mg/day of selegiline cause tyramine interaction

A

10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Part 4 of UPDRS of PD

A

hoehn and yahr staging

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

stage 4 BP

A

ECT 3 drug combo clozapine is part

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

AED for BP (4)

A

Valproic/ Divalproex CBZ LMG OXC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

define bradykinesia

A

slowness and poverty of movement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Part 3 of UPDRS of PD

A

clinician scored motor evaluation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Levodopa effects

A

most effective for sx

improve mortality

dec. rigidity/hypokinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

tx of wearing off in PD (4)

A

more frequent sinemet add DA agonist add maoi add comt

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

stage 3 BP

A

different 2 drug combo depressed: combo w/2 li, LMG, QUE, LUR, OLA-F

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

cabergoline MOA

A

long acting d2 agonist

low affinity 5ht agonist

antagonist of alpha adrenergic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Part 1 of UPDRS of PD

A

evaluation of mentation, behavior and mood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Acute Phase BP

A

keep full response >4 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

Stage 2 of PD

A

bilateral no postural abnormalities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

SE of alpha2 agonist

A

sedation rebound HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Stage 4 of PD

A

bilateral postural abnormalites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

hallucination in PD tx

A

pimavanserin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

tx of med related dystonia

A

dec. individual dose of sinemet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

indication for bromocriptine

A

hyperprolactinemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

psychosis in PD tx

A

eliminate ACH/DA agonist

add clozapine or quetiapine

56
Q

CBZ and lithium

A

inc. li ADE

57
Q

long acting stimulant duraiton

A

10-12 hours

58
Q

DSMv mania

A

sx >7 days 3+ sx (4 if mood only irritable)

59
Q

ace/arb and lithium

A

inc. li

60
Q

intermediate acting stimulant duration

A

3-8 hours

61
Q

Antiach for PD (2)

A

Benztropine Trihexylphenidyl

62
Q

DSMv hypomania

A

no delusions no hallucinations

63
Q

Amantadine MOA

A

release endogenous dA

block Da reuptake

can cross BBB

block glutamate receptor

64
Q

acute bp depression tx (3)

A

lithium LMG Ola-F

65
Q

Stage 5 of PD

A

severe fully developed disease bed or chair bound

66
Q

what antidepressant do you avoid in BP and MDD?

A

abilify

67
Q

Part 2 of UPDRS of PD

A

self evaluation of ADLs

68
Q

BP2

A

hypomnic MDE

69
Q

entacapone MOA

A

selective, reversible inhibitor of COMT does not cross BBB

70
Q

alpha2 adrenergic agonist for ADHD (2)

A

Guanfacine Clonidine

71
Q

TCA MOA ADHD

A

block NE and 5HT presynaptic transporter site

72
Q

stage 2 BP

A

2nd drug combo therapy -if depressed add lurasidone or olanzapine-fluoxetine

73
Q

acute mania w/ psychosis tx in BP

A

quetiapine + LI/DVP aripiprazole + Li/DVP Risperidone + Li/DVP Asenapine + Li/DVP

74
Q

alpha2 agoinst indicaiton (5)

A

monotherapy w/ tic disorder

aggression

anger

disruptive behavior

SE management: sleep

75
Q

how much carbidopa needed to inhibit decarboxylation and prevent N/V

A

75mg/day

76
Q

Methylphenidate - dexmethylphenidate MOA

A

block DA reuptake

77
Q

what sga treat mania and mdd

A

latuda seroquel

78
Q

atomoxetine MOA

A

selective NE reuptake inhibitor

79
Q

BP tx d/c

A

>6 months of remission

80
Q

tx of peak dose dyskinesias (5)

A

lower sinemet dose

amantadine >300mg/day

add DA agonist

Add comt inhibitor for sx

do not switch to CR sinemet

81
Q

week 4 BP

A

full: continue, m-m: inc. dose, next stage s: inc. dose, next stage

82
Q

Benztropine MOA

A

h1 antagonist inhibit DA reuptake

83
Q

2 TCA for ADHD

A

desipramine imipramine

84
Q

1st line agitation BP

A

Aripiprazole Lorazepam Loxapine Olanzapine

85
Q

anxiety tx in PD (2)

A

SSRI venlafaxine

86
Q

nsaids and lithium

A

in li

87
Q

ADHD and MVA

A

4x more serious MVA in ADHD

88
Q

safiniamide MOA

A

reversible inhibitor of MOAb

block na, ca channels

inhibit gluatamate release

89
Q

amphetamine MOA

A

enhance release of NE and DA

90
Q

Stage 3 of PD

A

bilateral mild postural abnormalities

91
Q

tx of disease related dystonia (2)

A

hs dose of sinemet cr

hs dose of DA agonist

92
Q

lithium CI (3)

A

CV disease

Kidney disease

untreated thyroid disorder

93
Q

ropinirole MOA

A

D2/D3 agonist

94
Q

Stimulants MOA

A

block NE and DA reuptake

95
Q

amantadine indication

A

initial for rigidity/bradykinesia

96
Q

week 8 BP

A

full: continue, transition? m-m: inc. dose, next stage s: next stage

97
Q

pramipexole renal adjustment

A

crcl <50

98
Q

mood stabilizer onset

A

7-14 days initial response 4-8 weeks ful response

99
Q

Freezing tx in pd

A

non-pharm first apomorphine

100
Q

Trimethobenzamide?

A

use with apomorphine for N/V 3 days prior and 60 days after

101
Q

MOA levodopa

A

increase DA in striatum BBB cross

102
Q

when to use lifetime mood stabilizers

A

>2manic episodes 1 severe manic episode

103
Q

alpha2 adrenergic agonist MOA

A

inhibit NE release

104
Q

DSMv ADHD

A

age 4-18 inattention

  • 6+ sx for 6+months
  • (>17 only need 5)

Hyper/impulsive

  • 6+ sx for 6+ months
105
Q

drugs that exacerbate dementia in PD (5)

A

Anti-ach

selegiline

amantadine

DA agonist

tCA

106
Q

other signs of PD

A

masked faces

hypophonia

micrographia

gait abnormaility

107
Q

tx of on-off fluctuation in pd (2)

A

add da agonist liquid sinemet

108
Q

short-acting stimulant duration

A

3-6 hours

109
Q

ssri/snri and lithium

A

inc. serotonin syndrome

110
Q

Week 6 BP

A

full: continue, transition? m-m: inc. dose, next stage s: inc dose, next stage

111
Q

atomoxetine onset

A

2-4 week 6-8 week max effect

112
Q

CI for alpha2agonist (2)

A

depression syncope dehydration

113
Q

ADHD tx ages 3-5

A

behavior mod

114
Q

BP 1

A

MANIC >7 days also MDE

115
Q

clinical presentation of PD acronym

A

TRAP T: tremor R: rigidity A: akinesia/bradykinesia P: postural instability

116
Q

Bupropion indication for ADHD

A

ADHD w/ depression

117
Q

BP 2 depression tx

A

quetiapine

118
Q

BP 2 hypomania tx (3)

A

lithium divalproex atypical

119
Q

MAO-B for PD (3)

A

Selegiline Rasagiline Safiniamide

120
Q

Part 5 of UPDRS of PD

A

schwab and england ADL scale

121
Q

2 main DA areas of brain for PD

A

substantia nigra nigrostriatal

122
Q

maintenance BP drugs (6)

A

lithium

LMG

Olanzapine

Aripiprazole

Risperdal consta

ziprasidone

123
Q

tx rapid cycling (3)

A

AED + AED

lithium + AED w/ atypical

Lithium or AED w/atypical

124
Q

type of dystonia (2)

A

disease related -early morning foot dystonia medication related

125
Q

what PD drug has more amount of motor complications

A

sinemet

126
Q

highest risk of antidepressant switching in order

A

TCA MAOI venlafaxine ssri bupropion

127
Q

caffeine, theophylline, osmotic diuretics and lithium

A

dec. li

128
Q

SE apomorphine (3)

A

powerful emetic qt prolongation priaprism

129
Q

TCA effect ADHD

A

dec. hyperactivity

improve mood and sleep

does not affect concentration

130
Q

BP 1,2 suicide risk?

A

2>1

131
Q

Benztropine indication

A

initial therapy for tremor

132
Q

depression tx in PD (5)

A

nortiptyline

desipramine

venlafaxine

citalopram

paroxetine

133
Q

what drugs for PD contain sulfites (2)

A

apomorphine Rotiogotine

134
Q

NOT recommended tx for BP (5)

A

2 antipsychotics

2 SRIs

SRI + MAOi

SRI + TCA

LMG + antidepressant

135
Q

anti-ach contraindication in PD

A

>65 cognitive impairment

136
Q

define rapid cycling

A

>4 mood disturbances in 12 months for MDD, mixed, manic, or hypomanic episode

IP3 (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions