Parkinson's

Question 1

What is Parkinson’s Disease?

Answer 1

Idiopathic Parkinson’s disease (PD) is a neurodegenerative disorder.

Question 2

What are the risk factors of parkinsons disease?

Answer 2

> Age
FHx
Mutation in gene encoding glucocerebrosidase
MPTP exposure

Question 3

What are the signs and symptoms of Parkinsons disease?

Answer 3

> Bradykinesia
> Resting tremor
> Rigidity
> Postural instability
> Hypomimic face
> Shuffling gait
> Depression, anxiety, dementia
> Fatigue, constipation, micrographia
> Hypokinetic dysarthria
> Conjugate gaze disorders

Question 4

What is the epidemiology of parkinsons disease?

Answer 4

With prevalence of disease increasing with age, PD is one of the most common neurodegenerative disorders. Given various age distributions in study populations, reports of incidence and prevalence vary. The overall age-adjusted prevalence of PD is 1% worldwide and 1.6% in Europe.

Question 5

What investigations would you do for parkinsons disease?

Answer 5

> Dopaminergic agent trial

> MRI brain