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24 Neurodegenerative diseases > Parkinson disease (dopamine receptor agonists) > Flashcards

Parkinson disease (dopamine receptor agonists) Flashcards

1
Q

Dopamine receptor agonists used in PD - 5 drugs

A 
Bromocriptine
Pramipexole
Ropinirole 
Rotigotine
Apomorphine
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2
Q

Dopamine receptor agonists - MOA

A

Directly activate dopamine D2 receptors in the striatum.
Inhibition of the indirect neuronal pathway from the striatum to the thalamus, and increase thalamic stimulation of the motor area of the cortex.

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3
Q

When are the dopamine receptor agonists useful and why?

A

Advanced cases of PD.

Do not require functional dopaminergic neurons.

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4
Q

Bromocriptine - MOA

A

D2-agonist, D1-antagonist

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5
Q

Bromocriptine - indications

A

Adjunct to levodopa.

Type 2 DIA

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6
Q

Bromocriptine - adverse effects

A

Confusion, hallucinations, sedation, vivid dreams, dyskinesias.
Decreased prolactin levels.
Dry mouth, nausea, orthostatic hypotension.

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7
Q

Which dopamine receptor agonists activates both D2 and D3 receptors?

A

Pramipexole

Rotigotine

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8
Q

Which drugs for PD are also indicated for restless leg syndrome?

A

Pramipexole.

Ropinirole

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9
Q

Pramipexole, ropinirole - adverse effects

A 
Dizziness
Hallucinations
Insomnia
Nausea
Vomiting
Sedation
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10
Q

Pramipexole - interactions

A

Cimetidine increases serum levels

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11
Q

Ropinirole - MOA

A

Selective D2-receptor agonist.

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12
Q

Ropinirole - interactions

A

Ciprofloxacin increases serum levels

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13
Q

Ropinirole, rotigotine, pramipexole - indications

A

Delay need for levodopa in early stages of PD. Advanced stages – reduce off period. Monotherapy

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14
Q

Rotigotine - contraindications

A

Sulfite sensitivity

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15
Q

Apomorphine - MOA

A

Dopamine receptor agonist that is chemically related to morphine

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16
Q

Apomorphine - indications

A

Acute, intermittent hypomobility episodes in advanced PD.

17
Q

Apomorphine - adm

A

Injection only

18
Q

Centrally acting ACh receptor antagonists used in PD

A

Benztropine

Trihexyphenidyl

19
Q

Benztropine - MOA

A

Like all central antiACh, it decreases the relative excess of ACh and has antihistamine activity.
In addition it inhibits neuronal reuptake of dopamine.

20
Q

Centrally acting ACh receptor antagonists - indictions in PD

A

Adjunct therapy for PD.
Most effective for reducing tremor.
Reduce parksonian symptoms caused by dopamine receptor antagonists.

21
Q

Centrally acting ACh receptor antagonists - adverse effects

A 
Agitation
Confusion
Constipation
Dry moth
Delirium
Memory loss
Urinary retention
Tachycardia
22
Q

Centrally acting ACh receptor antagonists - interactions

A

Additive anticholinergic effect with antihistamines and phenothiazides

24 Neurodegenerative diseases (7 decks)

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