Parenteral & Enteral Nutrition Support Flashcards

1
Q

When should nutriotnal support be considered?

A
  1. Cannot tolerate oral feeding
  2. Malnourished
    • BMI < 18.5 kg/m2
    • Unintentional weight loss > 10% in last 3-6 months
    • BMI < 20.0 kg/m2 and unintentional weight loss > 5% in last 3-6 months
  3. At risk of malnutrition
    • Little or no oral intake > 5 days and/or anticipated poor intake for at least another 5 days.
    • Poor absorptive capacity, high nutrient losses, increased nutritional requirements
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2
Q

Why is the GI tract preferred to eneteral support?

A
  • Maintain GI endocrine/exocrine secretions
  • Maintenance of GI integrity – tight junctions between intestinal epithelial cells require energy obtained directly from local absorption
  • Maintain GI microflora
  • Cheaper
  • Fewer complications
  • Safer
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3
Q

What are indications for Enteral Nutrition?

A
  • Dysphagia: Stroke, Neurological disease
  • Upper GI Obstruction: Stricture, Malignancy
  • Inability To Eat: Coma, ICU, Head & neck surgery
  • High Nutritional Requirements: Burns, Sepsis, Malignancy
  • Loss Of Appetite: Anorexia, Cancer
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4
Q

What are route for enteral feeding?

A
  • Naso-Gastric (NG) / Naso-Jejunal (NJ)
  • Percutaneous Endoscopic Gastrostomy (PEG)
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5
Q

What is the composition of enteral Feeds?

A

Commercially prepared feeds usually used, ‘standard’ feed has following characteristics:

  • Approx 1 kcal/mL
  • Isotonic
  • Contains fibre
  • Lactose free
  • Non hydrolysed protein content approx 40 g/L
  • Mixture of simple and complex CHOs
  • Long chain FAs (some medium chain and omega-3)
  • Essential vitamins and trace elements

Approx 50% calories supplied by CHO, 30% as fat. Additional fluids are also required and will vary according to patient requirements

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6
Q

What are Type of Enteral Feeds?

A

Concentrated

  • Critically ill patients requiring volume restriction
  • Hyperosmolar, up to 2 kcal/mL

Polymeric

  • Non hydrolysed intact protein as nitrogen source

Elemental/Pre-digested

  • Short oligopeptides provide nitrogen source
  • Less complex CHOs
  • Used for e.g malabsorption, short bowel

Disease specific

  • Paediatric in-born errors of metabolism – PKU feeds, renal failure feeds
  • Renal e.g low phosphate
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7
Q

What are some complicatons of Enteral Feeding?

A
  • Mechanical: Tube blockage, Tube misplacement (Aspiration), Physical damage
  • Gastrointestinal: Nausea, Constipation, Diarrhoea, Abdominal distension
  • Biochemical: Re-feeding, Electrolyte disturbances, Micronutrient deficiencies, Hyperglycaemia
  • Other: Infection
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8
Q

What is Parenteral Nutrition?

A
  • Parenteral is Intravenous
  • Reserved for patients in whom enteral intake is inadequate or unsafe, or where GI tract is non-functional or inaccessible
  • Although evidence suggests improved outcomes for malnourished patients on short term feeding, due to potential complications PN is rarely indicated for use for just a few days
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9
Q

What are indication for Paraenteral Nutrition?

A
  • Intestinal Failure / Short bowel
  • Inflammatory Bowel Disease – Chron’s, Ulcerative cholitis
  • GI obstruction – Malignancy, Stricture, Ileus
  • Gut ‘rest’ – Pancreatitis, Post-op bowel resection
  • Radiation enteritis
  • Congenital bowel defects in paediatrics
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10
Q

What are features of Short Term PN feeds?

A
  • PN feed osmolality approx 900-1500 mosmol/Kg
  • Plasma osmolality approx 290 mosmol/Kg
  • PN ideally infused into large central vein where rapid blood flow quickly dilutes the high osmolality feed
  • Infusion into peripheral veins can result in thrombophlebitis
  • Reduce glucose content of feed to reduce osmolality
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11
Q

How is PN administered in the long term?

A
  • Peripherally Inserted Central Catheter (PICC)
  • Tunelled central line eg Hickman line
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12
Q

What are the types of Infusion schedules for PN feeds?

A
  • Continuous
  • Cyclical
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13
Q

What are features of Continuous Infusion feeds?

A
  • Non-interrupted infusion over 24 hr
  • Well tolerated
  • Increased propensity for PN associated liver disease
  • Reduced mobility
  • Reduced quality of life
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14
Q

What are the features of Cyclical feeds?

A
  • Intermittent administration usually over 12-18 hr
  • Less well tolerated in critically ill patients
  • Approx. normal physiology of intermittent feeding
  • Improved mobility
  • Improved quality of life
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15
Q

Wat factors should be monitored when giving infusions of PN feeds?

A
  • Nutrient content of feed: Daily, reducing to twice weekly when stable
  • Volume of feed: Daily, reducing to twice weekly when stable
  • Weight: Daily if concerns regarding fluid balance, otherwise weekly reducing to monthly
  • Fluid Balance: Daily, then twice weekly when stable
  • Temperature/Blood pressure: Daily
  • Anthropometric measurements: Monthly
  • Evidence of GI dysfunction (vomiting, diarrhoea, constipation, abdominal distension): Daily, reducing to twice weekly
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16
Q

What are Paraenteral feed complications?

A

Lines

  • Infection
  • Air / Venous embolism
  • Blockage
  • Misplacement

Thrombophlebitis

  • Peripheral line administration

Metabolic

  • Re-feeding
  • Electrolyte disturbances
  • Micronutrient deficiencies
  • Hyperglycaemia
  • Bone disease

Liver disease

17
Q

What are signs of PNALD?

A
  • Common to find elevated bilirubin, ALP and ALT in patients on short term PN
  • Usually mild, transient and resolve once PN discontinued
  • PNALD – up to 60% children and 40% adults on long term PN
18
Q

What is Prolonged PN associated with in the Liver?

A
  • Hypertriglyceridaemia
  • Steatohepatitis
  • Cholestasis
  • Fibrosis / Cirrhosis – more common in paediatrics
19
Q

What is the Aetiology of PNALD?

A
  • Underlying Disease: Pre-existing liver disease, Sepsis, IBD, Intestinal bacterial overgrowth, Short bowel (impaired bile acid circulation/metabolism)
  • Lack of enteral nutrition
  • Parenteral nutrient deficiency: Protein, Essential FAs, Choline, Taurine, Carnitine
  • Parenteral nutrient toxicity: Glucose, Lipids, Mn, Al
20
Q

What is the treatment for PNALD?

A

Manage underlying disease:

  • Avoid and treat sepsis
  • Treat bacterial overgrowth
  • Avoid hepatotoxic medication
  • Treat underling liver disease

Modify enteral and parenteral nutrition:

  • Avoid overfeeding
  • Optimise parenteral lipid
  • Cyclical PN
  • Maximise enteral nutrition where possible

Pharmacological treatment:

  • Bile acid sequestrants – Ursodeoxycholic acid
  • Parenteral choline / taurine

Small intestine and/or liver transplantation. It has a 1 yr survival of:

  • Combined liver + SI = 60%
  • SI alone = 77%
21
Q

How can PN Fat Content after PNALD?

A

Composition of lipids in PN may have bearing on development of PNALD

  • Very small amount lipid required to provide essential fatty acids, but recommended ~50% kcal requirements derived from lipids
  • Lipid usually soyabean based long chain triglyceride (LCT) emulsified into chylomicrons with egg derived phospholipids
22
Q

What are other formulations of Fat in PN feeds that may reduce the likelihood of PNALD?

A
  • 50:50 LCT:MCT mixtures (MCTs possibly more easily absorbed and metabolised)
  • Monounsaturated fatty acids (MUFA)
  • Omega-3 fish oils / MCT (SMOF)

Cyclical lipid feeding also used to help avoid PNALD

23
Q

What afeatures of Home Parenteral Nutrtion?

A

An option for patients with medium/long term or permanent loss of gut function.

  • Quicker discharge from hospital
  • Improved rehabilitation in the home
  • Improved quality of life

Patients must be rigorously trained in sterile techniques for line care and line/feed handling

24
Q

What is required for Home Parenteral Nutrition?

A
  • Private home care nursing provider / GP funding
  • Regular visits from PN nurses
  • Facilities in the home for keeping PN bags at 4ºC plus lots of other kit (pump etc)
  • Self-care/self-awareness of eg infection, temperature
  • Regular clinic visits and bloods from overseeing hospital team